Evidence map›Paper›PMID 22319302›Full record

ArticleSensors (Basel, Switzerland)2010

Multiplexed electrochemical detection of Yersinia pestis and staphylococcal enterotoxin B using an antibody microarray.

Jason Wojciechowski, David Danley, John Cooper, Nina Yazvenko, Chris Rowe Taitt

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jason WojciechowskiCenter for Bio, Molecular Science and Engineering, Bld. 30, US Naval Research Laboratory, 4555 Overlook Ave. SW, Washington, DC 20376, USA. jason.wojciechowski.ctr@nrl.navy.mil
David Danley
John Cooper
Nina Yazvenko
Chris Rowe Taitt
CombiMatrix · USUnited States Naval Research Laboratory · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The CombiMatrix antibody microarray is a versatile, sensitive detection platform based on the generation and transduction of electrochemical signals following antigen binding to surface antibodies. The sensor chip described herein is comprised of microelectrodes coupled to an adjacent bio-friendly matrix coated with antibodies to the biological pathogens Yersinia pestis and Bacillus anthracis, and the bacterial toxin staphylococcal enterotoxin B (SEB). Using this system, we were able to detect SEB and inactivated Y. pestis individually as well as in two-plex assays at concentrations as low as 5 pg/mL and 10(6) CFU/mL, respectively. We also introduce super avidin-biotin system (SABS) as a viable and effective means to enhance assay signal responses and lower detection limits. Together these technologies represent substantial advances in point-of-care and point-of-use detection applications.

Indexed as

AntibodiesBacillus anthracisBiosensing TechniquesElectrochemical TechniquesEnterotoxinsHumansMicroelectrodesPoint-of-Care SystemsProtein Array AnalysisYersinia pestisAntibodiesenterotoxin B, staphylococcalEnterotoxinsbiosensorCombiMatrixelectrochemical detectionimmunoassaymicroarraypathogen detectionsuper avidin-biotin system (SABS)

Identifiers

PMID22319302
PMCPMC3274223
OpenAlexW1972447472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.