ArticleMolecular biology and evolution2012
Younger genes are less likely to be essential than older genes, and duplicates are less likely to be essential than singletons of the same age.
Article in Molecular biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Pleiotropy increases with gene age in six model multicellular eukaryotes.Evolution letters · 2025Article
- The quest for the best target genes for RNAi-mediated pest control.Insect molecular biology · 2025Review
- Mslar: Microbial synthetic lethal and rescue database.PLoS computational biology · 2023Review
- A pan-Zea genome map for enhancing maize improvement.Genome biology · 2022Article
- Functional compensation of mouse duplicates by their paralogs expressed in the same tissues.Genome biology and evolution · 2022Article
- The fate of drought-related genes after polyploidization inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Rapid Intraspecies Evolution of Fitness Effects of Yeast Genes.Genome biology and evolution · 2022Article
- Review
- Known allosteric proteins have central roles in genetic disease.PLoS computational biology · 2022Article
- Feature importance network reveals novel functional relationships between biological features inFrontiers in plant science · 2022Article
- Functional Heterogeneity of the Young and Old Duplicate Genes in Tung Tree (Frontiers in plant science · 2022Article
- Ancestry analysis indicates two different sets of essential genes in eukaryotic model species.Functional & integrative genomics · 2021Article
- On the relation of gene essentiality to intron structure: a computational and deep learning approach.Life science alliance · 2021Article
- The Transposable Element Environment of Human Genes Differs According to Their Duplication Status and Essentiality.Genome biology and evolution · 2021Article
- Region-specific expression of young small-scale duplications in the human central nervous system.BMC ecology and evolution · 2021Article
- Essential Genes of the Parasitic Apicomplexa.Trends in parasitology · 2021Review
- OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines.Nucleic acids research · 2021Article
- Article
- Dedicated transcriptomics combined with power analysis lead to functional understanding of genes with weak phenotypic changes in knockout lines.PLoS computational biology · 2020Article
- A spectrum of verticality across genes.PLoS genetics · 2020Article
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4 authors.
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Abstract
Recently duplicated genes are believed to often overlap in function and expression. A priori, they are thus less likely to be essential. Although this was indeed observed in yeast, mouse singletons and duplicates were reported to be equally often essential. This contradiction can only partly be explained by experimental biases. We herein show that older genes (i.e., genes with earlier phyletic origin) are more likely to be essential, regardless of their duplication status. At a given phyletic gene age, duplicates are always less likely to be essential compared with singletons. The "paradoxical" high essentiality among mouse gene duplicates is then caused by different age profiles of singletons and duplicates, with the latter tending to be derived from older genes.
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