ArticleMolecular biology and evolution2012
The voltage-gated potassium channel subfamily KQT member 4 (KCNQ4) displays parallel evolution in echolocating bats.
Article in Molecular biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 53 citations in OpenAlex.
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- Musculoskeletal morphogenesis supports the convergent evolution of bat laryngeal echolocation.Proceedings. Biological sciences · 2024Article
- Characterization of microRNA and gene expression in the cochlea of an echolocating bat (Ecology and evolution · 2022Article
- Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals.G3 (Bethesda, Md.) · 2021Article
- Echolocation call frequency variation in horseshoe bats: molecular basis revealed by comparative transcriptomics.Proceedings. Biological sciences · 2020Article
- A functional enrichment test for molecular convergent evolution finds a clear protein-coding signal in echolocating bats and whales.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Gene expression vs. sequence divergence: comparative transcriptome sequencing among naturalFrontiers in zoology · 2019Article
- Comparative Transcriptome Analyses Reveal the Role of Conserved Function in Electric Organ Convergence Across Electric Fishes.Frontiers in genetics · 2019Article
- Comparative cochlear transcriptomics of echolocating bats provides new insights into different nervous activities of CF bat species.Scientific reports · 2018Article
- Genomic and functional evidence reveals molecular insights into the origin of echolocation in whales.Science advances · 2018Article
- Article
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- Convergent Evolution of Head Crests in Two Domesticated Columbids Is Associated with Different Missense Mutations in EphB2.Molecular biology and evolution · 2015Article
- Are Convergent and Parallel Amino Acid Substitutions in Protein Evolution More Prevalent Than Neutral Expectations?Molecular biology and evolution · 2015Article
- No genome-wide protein sequence convergence for echolocation.Molecular biology and evolution · 2015Article
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8 authors at 4 institutions in 3 countries.
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Abstract
Bats are the only mammals that use highly developed laryngeal echolocation, a sensory mechanism based on the ability to emit laryngeal sounds and interpret the returning echoes to identify objects. Although this capability allows bats to orientate and hunt in complete darkness, endowing them with great survival advantages, the genetic bases underlying the evolution of bat echolocation are still largely unknown. Echolocation requires high-frequency hearing that in mammals is largely dependent on somatic electromotility of outer hair cells. Then, understanding the molecular evolution of outer hair cell genes might help to unravel the evolutionary history of echolocation. In this work, we analyzed the molecular evolution of two key outer hair cell genes: the voltage-gated potassium channel gene KCNQ4 and CHRNA10, the gene encoding the α10 nicotinic acetylcholine receptor subunit. We reconstructed the phylogeny of bats based on KCNQ4 and CHRNA10 protein and nucleotide sequences. A phylogenetic tree built using KCNQ4 amino acid sequences showed that two paraphyletic clades of laryngeal echolocating bats grouped together, with eight shared substitutions among particular lineages. In addition, our analyses indicated that two of these parallel substitutions, M388I and P406S, were probably fixed under positive selection and could have had a strong functional impact on KCNQ4. Moreover, our results indicated that KCNQ4 evolved under positive selection in the ancestral lineage leading to mammals, suggesting that this gene might have been important for the evolution of mammalian hearing. On the other hand, we found that CHRNA10, a gene that evolved adaptively in the mammalian lineage, was under strong purifying selection in bats. Thus, the CHRNA10 amino acid tree did not show echolocating bat monophyly and reproduced the bat species tree. These results suggest that only a subset of hearing genes could underlie the evolution of echolocation. The present work continues to delineate the genetic bases of echolocation and ultrasonic hearing in bats.
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