ArticleProceedings. Biological sciences2012
The penetrance of an epigenetic trait in mice is progressively yet reversibly increased by selection and environment.
Article in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- A conceptual framework for understanding stress-induced physiological and transgenerational effects on population responses to climate change.Evolution letters · 2024Article
- Adapting to climate with limited genetic diversity: Nucleotide, DNA methylation and microbiome variation among populations of the social spider Stegodyphus dumicola.Molecular ecology · 2022Article
- Obesity III: Obesogen assays: Limitations, strengths, and new directions.Biochemical pharmacology · 2022Review
- Pollution induces epigenetic effects that are stably transmitted across multiple generations.Evolution letters · 2022Article
- Remodeling the epigenome and (epi)cytoskeleton: a new paradigm for co-regulation by methylation.The Journal of experimental biology · 2020Review
- DNA methylation in canine brains is related to domestication and dog-breed formation.PloS one · 2020Article
- CDX1/2 and KLF5 Expression and Epigenetic Modulation of Sonic Hedgehog Signaling in Gastric Adenocarcinoma.Pathology oncology research : POR · 2019Article
- Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity.Molecular metabolism · 2016Article
- Epigenetic response to environmental change: DNA methylation varies with invasion status.Environmental epigenetics · 2016Article
- The role of non-genetic inheritance in evolutionary rescue: epigenetic buffering, heritable bet hedging and epigenetic traps.Environmental epigenetics · 2016Article
- From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?Clinical epigenetics · 2015Article
- Maternal methyl supplemented diets and effects on offspring health.Frontiers in genetics · 2014Review
- Article
- Epigenetic regulation of asthma and allergic disease.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2014Review
- Article
- A role for epigenetic inheritance in modern evolutionary theory? A comment in response to Dickins and Rahman.Proceedings. Biological sciences · 2013Article
- Epigenetic inheritance of disease and disease risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Review
- Epigenetic inheritance: a contributor to species differentiation?DNA and cell biology · 2012Review
- The secret language of destiny: stress imprinting and transgenerational origins of disease.Frontiers in genetics · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural selection acts on variation that is typically assumed to be genetic in origin. But epigenetic mechanisms, which are interposed between the genome and its environment, can create diversity independently of genetic variation. Epigenetic states can respond to environmental cues, and can be heritable, thus providing a means by which environmentally responsive phenotypes might be selectable independent of genotype. Here, we have tested the possibility that environment and selection can act together to increase the penetrance of an epigenetically determined phenotype. We used isogenic A(vy) mice, in which the epigenetic state of the A(vy) allele is sensitive to dietary methyl donors. By combining methyl donor supplementation with selection for a silent A(vy) allele, we progressively increased the prevalence of the associated phenotype in the population over five generations. After withdrawal of the dietary supplement, the shift persisted for one generation but was lost in subsequent generations. Our data provide the first demonstration that selection for a purely epigenetic trait can result in cumulative germline effects in mammals. These results present an alternative to the paradigm that natural selection acts only on genetic variation, and suggest that epigenetic changes could underlie rapid adaptation of species in response to natural environmental fluctuations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.