ArticleAmerican journal of physiology. Endocrinology and metabolism2012
Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals.
Article in American journal of physiology. Endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 101 citations in OpenAlex.
- Uncovering genetic variations in HTR2A and miRNAs drivers of breast cancer risk in African American women.Journal of breast cancer research · 2026Article
- Effects of Pregnancy and Lactation on Bone Microstructure and Material Properties in a Rat Model of Bariatric Surgery.Calcified tissue international · 2025Article
- Zeolite for preventing periparturient hypocalcemia in dairy cows: mechanisms and application strategies.Frontiers in veterinary science · 2025Review
- Effects of induced subclinical hypocalcemia in early-lactation Holstein cows without milking during infusion on parathyroid hormone and serotonin concentrations.JDS communications · 2024Article
- Exploring the contribution of mammary-derived serotonin on liver and pancreas metabolism during lactation.PloS one · 2024Article
- The antidepressant fluoxetine (Prozac®) modulates serotonin signaling to alter maternal peripartum calcium homeostasis.Scientific reports · 2023Article
- The Serotonergic System and Bone Metabolism During Pregnancy and Lactation and the Implications of SSRI Use on the Maternal-Offspring Dyad.Journal of mammary gland biology and neoplasia · 2023Review
- 5-Hydroxytryptophan inhibits β-casein biosynthesis and promotes goat mammary epithelial cell apoptosis through the JAK2/STAT5a axis and the HTR7.Journal of animal science · 2023Article
- Crosstalk within a brain-breast-bone axis regulates mineral and skeletal metabolism during lactation.Frontiers in physiology · 2023Review
- Fluoxetine treatment during the postpartal period may have short-term impacts on murine maternal skeletal physiology.Frontiers in pharmacology · 2023Article
- Increasing serotonin concentrations alter calcium metabolism in periparturient dairy goats.Journal of animal science · 2022Article
- Peripartal treatment with low-dose sertraline accelerates mammary gland involution and has minimal effects on maternal and offspring bone.Physiological reports · 2022Article
- Impact of Fluoxetine Treatment and Folic Acid Supplementation on the Mammary Gland Transcriptome During Peak Lactation.Frontiers in pharmacology · 2022Article
- Elevated serotonin coordinates mammary metabolism in dairy cows.Physiological reports · 2021Article
- Regulation of cellular senescence by eukaryotic members of the FAH superfamily - A role in calcium homeostasis?Mechanisms of ageing and development · 2020Review
- Article
- Serotonin regulates maternal calcium homeostasis during the perinatal period of sheep.Journal of animal science · 2019Article
- Prolactin and human weight disturbances: A puzzling and neglected association.Reviews in endocrine & metabolic disorders · 2019Review
- In utero and lactational exposure to the Selective Serotonin Reuptake Inhibitor fluoxetine compromises pup bones at weaning.Scientific reports · 2019Article
- Peripartum dietary supplementation of a small-molecule inhibitor of tryptophan hydroxylase 1 compromises infant, but not maternal, bone.American journal of physiology. Endocrinology and metabolism · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Breast cells drive bone demineralization during lactation and metastatic cancers. A shared mechanism among these physiological and pathological states is endocrine secretion of parathyroid hormone-related protein (PTHrP), which acts through osteoblasts to stimulate osteoclastic bone demineralization. The regulation of PTHrP has not been accounted for fully by any conventional mammotropic stimuli or tumor growth factors. Serotonin (5-HT) synthesis within breast epithelial cells is induced during lactation and in advancing breast cancer. Here we report that serotonin deficiency (knockout of tryptophan hydroxylase-1) results in a reduction of mammary PTHrP expression during lactation, which is rescued by restoring 5-HT synthesis. 5-HT induced PTHrP expression in lactogen-primed mammary epithelial cells from either mouse or cow. In human breast cancer cells 5-HT induced both PTHrP and the metastasis-associated transcription factor Runx2/Cbfa1. Based on receptor expression and pharmacological evidence, the 5-HT2 receptor type was implicated as being critical for induction of PTHrP and Runx2. These results connect 5-HT synthesis to the induction of bone-regulating factors in the normal mammary gland and in breast cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.