ArticleCarcinogenesis2012
Leukocyte telomere length predicts overall survival in hepatocellular carcinoma treated with transarterial chemoembolization.
Article in Carcinogenesis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between telomere length and survival in cancer patients: a meta-analysis and review of literature.Frontiers of medicine · 2016Pooled it
- The Association between Telomere Length and Cancer Prognosis: Evidence from a Meta-Analysis.PloS one · 2015Pooled it
- The correlation between telomere length of the peripheral blood basophil and the risk and prognosis of hepatocellular carcinoma.Discover oncology · 2026Article
- Clinical utility of telomeres as diagnostic and short-term prognostic markers in loco-regional treatment of hepatocellular carcinoma.World journal of gastroenterology · 2025Article
- Causal relationships between telomere length and liver disease: a Mendelian randomization study.Frontiers in genetics · 2023Article
- Tieing together loose ends: telomere instability in cancer and aging.Molecular oncology · 2022Review
- Shorter Leukocyte Telomere Length Is Associated with Worse Survival of Patients with Bladder Cancer and Renal Cell Carcinoma.Cancers · 2021Article
- The role of telomeres and telomerase in cirrhosis and liver cancer.Nature reviews. Gastroenterology & hepatology · 2019Review
- Article
- Relative telomere length and prostate cancer mortality.Prostate cancer and prostatic diseases · 2018Article
- Telomere Length and Lung Cancer Mortality among Heavy Smokers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study.International journal of cancer · 2018Article
- Telomere Length Dynamics and the Evolution of Cancer Genome Architecture.International journal of molecular sciences · 2018Review
- Telomere length variation in tumor cells and cancer-associated fibroblasts: potential biomarker for hepatocellular carcinoma.The Journal of pathology · 2017Article
- Paired assessment of liver telomere lengths in hepatocellular cancer is a reliable predictor of disease persistence.Bioscience reports · 2017Article
- Telomere length in peripheral leukocytes is associated with immune cell tumor infiltration and prognosis in colorectal cancer patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Hypersplenism is correlated with increased risk of hepatocellular carcinoma in patients with post-hepatitis cirrhosis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Telomere Length and Survival of Patients with Hepatocellular Carcinoma in the United States.PloS one · 2016Article
- Leukocyte telomere length: a novel biomarker to predict the prognosis of glioma patients.Journal of cancer research and clinical oncology · 2015Article
- Short telomere length in peripheral blood leukocyte predicts poor prognosis and indicates an immunosuppressive phenotype in gastric cancer patients.Molecular oncology · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Previous studies have reported that telomere length in peripheral blood leukocytes can predict the clinical outcome of several cancers. However, whether leukocyte telomere length is associated with the prognosis of hepatocellular carcinoma (HCC) remains to be determined. In this study, relative telomere length (RTL) in peripheral blood leukocytes was measured using a real-time PCR-based method for 269 HCC patients treated with transarterial chemoembolization (TACE) from two independent hospitals. The association between RTL and the overall survival (OS) of HCC was analyzed. The immunological function of the HCC patients with different leukocyte RTLs was evaluated. Multivariate analyses indicated that long leukocyte RTL was significantly associated with poor OS of HCC patients, with a hazard ratio of 2.04 (95% confidence interval, 1.46-2.86; P < 0.001). Kaplan-Meier analyses showed a significant difference of median survival time between patients with long and short RTL (log rank P < 0.001). Fluorescence-activated cell sorting analyses showed that the long RTL group had a significantly increased percentage of CD4(+)CD25(+)FOXP3(+) Treg in CD4(+) T cells compared with short RTL group (P = 0.002). In conclusion, our results suggest that leukocyte RTL may serve as an independent prognostic marker for HCC patients treated with TACE.
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