ArticleDevelopment (Cambridge, England)2012
Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specification.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- The Tbx1 ortholog org-1 is required to establish testis stem cell niche identity in Drosophila.Development (Cambridge, England) · 2026Article
- In Vivo Models of Cardiovascular Disease:Biomedicines · 2025Review
- The Hox protein Antennapedia orchestratesScience advances · 2024Article
- New insights into mesoderm and endoderm development, and the nature of the onychophoran blastopore.Frontiers in zoology · 2024Article
- Establishment of the Myeloid TBX-Code Reveals Aberrant Expression of T-Box Gene TBX1 in Chronic Myeloid Leukemia.International journal of molecular sciences · 2023Article
- Drosophila as a Model to Understand Second Heart Field Development.Journal of cardiovascular development and disease · 2023Review
- The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila.Development (Cambridge, England) · 2023Article
- Insights and perspectives on the enigmatic alary muscles of arthropods.Frontiers in cell and developmental biology · 2023Review
- Specificity of the Hox member Deformed is determined by transcription factor levels and binding site affinities.Nature communications · 2022Article
- Gelsolin and dCryAB act downstream of muscle identity genes and contribute to preventing muscle splitting and branching in Drosophila.Scientific reports · 2021Article
- Review
- A Large Scale Systemic RNAi Screen in the Red Flour BeetleG3 (Bethesda, Md.) · 2019Article
- RNAi Screen inG3 (Bethesda, Md.) · 2019Article
- The Zic family homologue Odd-paired regulates Alk expression in Drosophila.PLoS genetics · 2017Article
- Rewiring of an ancestral Tbx1/10-Ebf-Mrf network for pharyngeal muscle specification in distinct embryonic lineages.Development (Cambridge, England) · 2016Article
- On the Morphology of the Drosophila Heart.Journal of cardiovascular development and disease · 2016Review
- Regulatory Networks that Direct the Development of Specialized Cell Types in theJournal of cardiovascular development and disease · 2016Article
- Review
- Muscle cell fate choice requires the T-box transcription factor midline in Drosophila.Genetics · 2015Article
- Distinct functions of the laminin β LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila.BMC developmental biology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Members of the T-Box gene family of transcription factors are important players in regulatory circuits that generate myogenic and cardiogenic lineage diversities in vertebrates. We show that during somatic myogenesis in Drosophila, the single ortholog of vertebrate Tbx1, optomotor-blind-related-gene-1 (org-1), is expressed in a small subset of muscle progenitors, founder cells and adult muscle precursors, where it overlaps with the products of the muscle identity genes ladybird (lb) and slouch (slou). In addition, org-1 is expressed in the lineage of the heart-associated alary muscles. org-1 null mutant embryos lack Lb and Slou expression within the muscle lineages that normally co-express org-1. As a consequence, the respective muscle fibers and adult muscle precursors are either severely malformed or missing, as are the alary muscles. To address the mechanisms that mediate these regulatory interactions between Org-1, Lb and Slou, we characterized distinct enhancers associated with somatic muscle expression of lb and slou. We demonstrate that these lineage- and stage-specific cis-regulatory modules (CRMs) bind Org-1 in vivo, respond to org-1 genetically and require T-box domain binding sites for their activation. In summary, we propose that org-1 is a common and direct upstream regulator of slou and lb in the developmental pathway of these two neighboring muscle lineages. Cross-repression between slou and lb and combinatorial activation of lineage-specific targets by Org-1-Slou and Org-1-Lb, respectively, then leads to the distinction between the two lineages. These findings provide new insights into the regulatory circuits that control the proper pattering of the larval somatic musculature in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.