ArticleDevelopment (Cambridge, England)2012
Dual transcriptional activities of SIX proteins define their roles in normal and ectopic eye development.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 84 citations in OpenAlex.
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- Comparative Analysis of Convergent Jellyfish Eyes Reveals Extensive Differences in Expression of Vision-Related Genes.Ecology and evolution · 2025Article
- Targeting sine oculis homeoprotein 1 (SIX1): A review of oncogenic roles and potential natural product therapeutics.Heliyon · 2024Review
- Canalizing cell fate by transcriptional repression.Molecular systems biology · 2024Review
- Retinal determination gene networks: from biological functions to therapeutic strategies.Biomarker research · 2023Review
- Zmym4 is required for early cranial gene expression and craniofacial cartilage formation.Frontiers in cell and developmental biology · 2023Article
- Development of the ocellar visual system in Drosophila melanogaster.The FEBS journal · 2022Article
- Mcrs1 is required for branchial arch and cranial cartilage development.Developmental biology · 2022Article
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- The timing of cell fate decisions is crucial for initiating pattern formation in the Drosophila eye.Development (Cambridge, England) · 2022Article
- Mcrs1 interacts with Six1 to influence early craniofacial and otic development.Developmental biology · 2020Article
- The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma.International journal of molecular sciences · 2020Review
- Co-transplantation with adipose-derived cells to improve parathyroid transplantation in a mice model.Stem cell research & therapy · 2020Article
- Recapitulating developmental mechanisms for retinal regeneration.Progress in retinal and eye research · 2020Review
- Identification of genomic enhancers through spatial integration of single-cell transcriptomics and epigenomics.Molecular systems biology · 2020Article
- Mitotic chromosome binding predicts transcription factor properties in interphase.Nature communications · 2019Article
- Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration.Molecular neurobiology · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The SIX family of homeodomain-containing DNA-binding proteins play crucial roles in both Drosophila and vertebrate retinal specification. In flies, three such family members exist, but only two, Sine oculis (So) and Optix, are expressed and function within the eye. In vertebrates, the homologs of Optix (Six3 and Six6) and probably So (Six1 and Six2) are also required for proper eye formation. Depending upon the individual SIX protein and the specific developmental context, transcription of target genes can either be activated or repressed. These activities are thought to occur through physical interactions with the Eyes absent (Eya) co-activator and the Groucho (Gro) co-repressor, but the relative contribution that each complex makes to overall eye development is not well understood. Here, we attempt to address this issue by investigating the role that each complex plays in the induction of ectopic eyes in Drosophila. We fused the VP16 activation and Engrailed repressor domains to both So and Optix, and attempted to generate ectopic eyes with these chimeric proteins. Surprisingly, we find that So and Optix must initially function as transcriptional repressors to trigger the formation of ectopic eyes. Both factors appear to be required to repress the expression of non-retinal selector genes. We propose that during early phases of eye development, SIX proteins function, in part, to repress the transcription of non-retinal selector genes, thereby allowing induction of the retina to proceed. This model of repression-mediated induction of developmental programs could have implications beyond the eye and might be applicable to other systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.