ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2012
Detection of human rhinovirus C in fecal samples of children with gastroenteritis.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Viral metagenomics reveals diverse viruses in the fecal samples of children with acute respiratory infection.Frontiers in microbiology · 2025Article
- Viruses Associated with Acute Conjunctivitis in Vanuatu.The American journal of tropical medicine and hygiene · 2023Article
- Equine rhinitis B viruses in horse fecal samples from the Middle East.Virology journal · 2016Article
- Enterovirus D68 Infections Associated with Severe Respiratory Illness in Elderly Patients and Emergence of a Novel Clade in Hong Kong.Scientific reports · 2016Article
- Review
- Disseminated rhinovirus C8 infection with infectious virus in blood and fatal outcome in a child with repeated episodes of bronchiolitis.Journal of clinical microbiology · 2015Article
- Epidemiologic, clinical, and virologic characteristics of human rhinovirus infection among otherwise healthy children and adults: rhinovirus among adults and children.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015Observational
- The Fecal Virome of Children with Hand, Foot, and Mouth Disease that Tested PCR Negative for Pathogenic Enteroviruses.PloS one · 2015Article
- Epidemiology of human parechovirus, Aichi virus and salivirus in fecal samples from hospitalized children with gastroenteritis in Hong Kong.Virology journal · 2014Article
- Emerging respiratory viruses other than influenza.Clinics in laboratory medicine · 2014Review
- Molecular detection of gastrointestinal viral infections in hospitalized patients.Diagnostic microbiology and infectious disease · 2013Article
- Recombinant coxsackievirus A2 and deaths of children, Hong Kong, 2012.Emerging infectious diseases · 2013Article
- A newly designed real-time RT-PCR for SAFV detects SAFV-2 and SAFV-3 in the respiratory tracts of ill children during 2011.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite recent discovery of the novel human rhinovirus species, HRV-C, little is known about the association of HRV-C in diseases other than respiratory tract infections.
objectivesTo investigate the presence of HRV-C in fecal samples of children with gastroenteritis. STUDY
design734 fecal samples from hospitalized children with gastroenteritis were subject to picornavirus detection by RT-PCR of the conserved 5'-NCR. Positive samples were subject to VP4 and 3D(pol) gene analysis for species determination. The clinical and molecular epidemiology of HRV-C and other picornaviruses was analyzed.
resultsPicornaviruses were detected in 113 (15.4%) of 734 fecal samples from children with gastroenteritis by RT-PCR of 5'-NCR, with 58 containing potential HRVs and 55 containing other enteroviruses. PCR of the VP4 and 3D(pol) regions was positive in 21 and 19 samples respectively (both regions positive in 8 samples). Sequencing analysis showed the presence of HRV-C in four samples, and diverse picornaviruses including HRV-A (n=2), HEV-A (n=2), HEV-B (n=2), HEV-C (n=21) and HPeV (n=2) in other samples, with co-detection of HRV-C and HPeV in one sample. Of the four children with HRV-C detected in fecal samples, three presented with diarrhea in the absence of respiratory symptoms, while one also had acute bronchiolitis. The four HRV-C strains from fecal samples belonged to the existing clade of diverse HRV-C genotypes, indistinguishable from previous respiratory strains.
conclusionsHRV-C can be detected in fecal samples of children with gastroenteritis, in the absence of respiratory symptoms. This study also represented the first to detect HPeV in our population.
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