ArticleJournal of experimental & clinical cancer research : CR2012
PinX1 regulation of telomerase activity and apoptosis in nasopharyngeal carcinoma cells.
Article in Journal of experimental & clinical cancer research : CR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Prognostic and Clinicopathological Value ofBioMed research international · 2018Pooled it
- PinX1 inhibits migrasomes-mediated mitochondrial transfer to confer cisplatin sensitivity in nasopharyngeal carcinoma.Oncogene · 2026Article
- PinX1 plays multifaceted roles in human cancers: a review and perspectives.Molecular biology reports · 2024Review
- hTERT gene knockdown enhances response to radio- and chemotherapy in head and neck cancer cell lines through a DNA damage pathway modification.Scientific reports · 2018Article
- Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer.Oncology reports · 2017Article
- Expression of FOXC2, PinX1, Ki-67 and Cyclin D1 in cutaneous cell carcinoma.Oncology letters · 2017Article
- PinX1: structure, regulation and its functions in cancer.Oncotarget · 2016Review
- Article
- PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-κB/MMP-9 signaling pathway.Molecular cancer · 2015Article
- Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma.Journal of experimental & clinical cancer research : CR · 2014Article
- PinX1-siRNA/mPEG-PEI-SPION combined with doxorubicin enhances the inhibition of glioma growth.Experimental and therapeutic medicine · 2014Article
- Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model.Journal of experimental & clinical cancer research : CR · 2014Article
- Reduced expression of PinX1 correlates to progressive features in patients with prostate cancer.Cancer cell international · 2014Article
- The role of PinX1 in growth control of breast cancer cells and its potential molecular mechanism by mRNA and lncRNA expression profiles screening.BioMed research international · 2014Article
- On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.Journal of experimental & clinical cancer research : CR · 2013Article
- Cause-specific telomere factors deregulation in hepatocellular carcinoma.Journal of experimental & clinical cancer research : CR · 2013Article
- Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation.Journal of experimental & clinical cancer research : CR · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be a putative tumor suppressor gene. Loss of PinX1 has been found in a large variety of malignancies, however, its function in inhibiting telomerase activity of tumor cells is not well documented. Here we show that PinX1 is essential for down-regulation telomerase activity of nasopharyngeal carcinoma.
methodsExpression vectors of human PinX1 (pEGFP-C3-PinX1) and its small interfering RNA (PinX1-FAM-siRNA) were constructed and transfected into NPC. Their effects on mRNA of telomerase catalytic subunit (hTERT), telomerase activity, cell proliferation, cell migration, wound healing, cell cycles and apoptosis were examined using semi-quantitative RT-PCR, stretch PCR, MTT assay, Transwell, scratch assay and flow cytometry, respectively.
resultsTransfection of pEGFP-C3-PinX1 and PinX1-FAM-siRNA increased and reduced PinX1 mRNA by 1.6-fold and 70%, respectively. Over-expression of PinX1 decreased hTERT mRNA by 21%, reduced telomerase activity, inhibited cell growth, migration and wound healing ability, arrested cells in G0/G1 phase, and increased apoptotic index. In contrast, down-regulation of PinX1 did not alter the above characteristics.
conclusionsPinX1 may play important roles in NPC proliferation, migration and apoptosis and has application potential in tumor-targeted gene therapy.
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