Trial reportJournal of the American Geriatrics Society2012
FRAX or fiction: determining optimal screening strategies for treatment of osteoporosis in residents in long-term care facilities.
Trial report in Journal of the American Geriatrics Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Fracture risk in long term care: a systematic review and meta-analysis of prospective observational studies.BMC geriatrics · 2014Pooled it
- Efficacy and safety of single-dose zoledronic acid for osteoporosis in frail elderly women: a randomized clinical trial.JAMA internal medicine · 2015Trial
- Validation of Ten Osteoporosis Screening Tools in Rural Communities of Taiwan.Calcified tissue international · 2024Article
- Development and validation of the fall-related injury risk in nursing homes (INJURE-NH) prediction tool.Journal of the American Geriatrics Society · 2023Article
- Screening of Fracture Risk and Osteoporosis Among Older Long-term Care Residents: A Prospective Study.The journal of nutrition, health & aging · 2023Article
- Controversies in Osteoporosis Treatment of Nursing Home Residents.Journal of the American Medical Directors Association · 2022Review
- The clinician's guide to prevention and treatment of osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Improving shared decision-making for osteoporosis pharmacologic therapy in nursing homes: a qualitative analysis.Archives of osteoporosis · 2022Article
- Establishing the Link Between Lean Mass and Grip Strength Cut Points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Article
- Review
- Exploring the nurse practitioner role in managing fractures in long-term care.Clinical nursing research · 2015Article
- Dosing Strategies of Bone-Targeting Agents-Reply.JAMA internal medicine · 2015Article
- Diagnostic criteria for osteoporosis should be expanded.The lancet. Diabetes & endocrinology · 2015Article
- Individuals with neurological diseases are at increased risk of fractures within 180 days of admission to long-term care in Ontario.Age and ageing · 2015Article
- Recent advances: osteoporosis in the "oldest old".Current osteoporosis reports · 2013Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo examine screening strategies for osteoporosis and fractures for treatment of long-term care residents.
designCross-sectional analysis to examine screening strategies for treatment.
settingAssisted living and skilled care facilities.
participantsTwo hundred two frail women aged 65 and older (mean 85), excluding those receiving bisphosphonates. MEASUREMENTS: Clinical fractures of the hip or spine (Clin Fx); Clin Fx or bone mineral density (BMD); Clin Fx, BMD, or vertebral fractures (VF) assessed according to dual-energy X-ray absorptiometry-based vertebral fracture assessments; fracture risk algorithm using femoral neck BMD (FRAX-FN); fracture risk algorithm using body mass index (FRAX-BMI); or Clin Fx or heel ultrasound (heel US).
resultsTreatment eligibility ranged from 17% (Clin Fx) to 98% (FRAX-BMI). VFs were found in 47%, 74% of which were silent. Criteria with Clin Fx, BMD, or VF identified 73% of study participants for treatment. FRAX-FN suggested treatment in 81% but would have missed approximately 10% of individuals with silent VFs. Clin Fx or heel US suggested that 39% of participants were eligible for treatment.
conclusionLong-term care residents eligible for osteoporosis treatment ranged from fewer than 20% to roughly all residents depending on screening criteria. VFs are common and identify a subset of residents missed by conventional BMD scans or FRAX-FN. A reasonable clinical approach could consider treatment for those with Clin Fx of the hip or spine, radiological evidence of a VF, or osteoporosis according to BMD classification. Prospective studies are needed to determine optimal screening strategies for treatment in this cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.