ReviewCritical care (London, England)2012
Clinical review: sepsis and septic shock--the potential of gene arrays.
Review in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transcriptomic meta-analysis reveals up-regulation of gene expression functional in osteoclast differentiation in human septic shock.PloS one · 2017Pooled it
- From cardiac injury to omics signatures: a narrative review on biomarkers in septic cardiomyopathy.Clinical and experimental medicine · 2025Review
- Genetic polymorphisms, biomarkers and signaling pathways associated with septic shock: from diagnosis to therapeutic targets.Burns & trauma · 2024Review
- Multilevel omics for the discovery of biomarkers in pediatric sepsis.Pediatric investigation · 2023Review
- Identification of potential hub genes linked to immune and metabolic alterations in postoperative systemic inflammatory dysregulation.Frontiers in immunology · 2023Article
- Current Challenges in the Management of Sepsis and Septic Shock: Personalized, Physiology-Guided Treatment.Journal of clinical medicine · 2022Article
- Impact of Inherited Genetic Variants on Critically Ill Septic Children.Pathogens (Basel, Switzerland) · 2022Review
- Low ZCCHC9 Gene Expression in Peripheral Blood May Be an Acute Myocardial Infarction Genetic Molecular Marker in Patients with Stable Coronary Atherosclerotic Disease.International journal of general medicine · 2022Article
- Endothelial Damage in Sepsis: The Importance of Systems Biology.Frontiers in pediatrics · 2022Review
- Serum proteomics reveals disorder of lipoprotein metabolism in sepsis.Life science alliance · 2021Article
- Effect of zinc supplementation on relative expression of immune response genes in neonates with sepsis: A preliminary study.The Indian journal of medical research · 2020Article
- Development of a Bioinformatics Framework for Identification and Validation of Genomic Biomarkers and Key Immunopathology Processes and Controllers in Infectious and Non-infectious Severe Inflammatory Response Syndrome.Frontiers in immunology · 2020Article
- Use of gene expression studies to investigate the human immunological response to malaria infection.Malaria journal · 2019Review
- Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis.Aging and disease · 2019Article
- Leukocyte Transcriptional Response in Sepsis.Shock (Augusta, Ga.) · 2019Article
- LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent.Scientific reports · 2018Article
- Application of Monte Carlo cross-validation to identify pathway cross-talk in neonatal sepsis.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Induction of the pneumococcal vncRS operon by lactoferrin is essential for pneumonia.Virulence · 2018Article
- Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality.Intensive care medicine experimental · 2017Article
- Biomarker candidates for the detection of an infectious etiology of febrile neutropenia.Infection · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Over the past decade several investigators have applied microarray technology and related bioinformatic approaches to clinical sepsis and septic shock, thus allowing for an assessment of how, or if, this branch of genomic medicine has meaningfully impacted the field of sepsis research. The ability to simultaneously and efficiently measure the steady-state mRNA abundance of thousands of transcripts from a given tissue source (that is, 'transcriptomics') has provided an unprecedented opportunity to gain a broader, genome-level 'picture' of complex and heterogeneous clinical syndromes such as sepsis. A trancriptomic approach to sepsis and septic shock is technically challenging on multiple levels, but nonetheless modest, tangible advances are being realized. These include a genome-level understanding of the complexity of sepsis and septic shock, identification of novel candidate pathways and targets for potential intervention, discovery of novel, candidate diagnostic and stratification biomarkers, and the ability to stratify patients into clinically relevant, expression-based subclasses. The challenges moving forward include robust validation studies, standardization of technical approaches, standardization and further development of analytical algorithms, and large-scale collaborations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.