ArticleJournal of the American Geriatrics Society2012
Lifestyle behavior pattern is associated with different levels of risk for incident dementia and Alzheimer's disease: the Cache County study.
Article in Journal of the American Geriatrics Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Combining modifiable risk factors and risk of dementia: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis.BMC public health · 2014Pooled it
- How Healthy and Unhealthy Lifestyle Behaviors Affect Cognitive Function-Evidence From Older Adults in Chinese Communities: Cross-Sectional Study.JMIR public health and surveillance · 2025Article
- Social determinants of health and risk of dementia among older men and women: A 12-year cohort study in Australia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cognitive function differs across healthy lifestyle behavior profiles: a 10-year population-based prospective cohort study.The journal of nutrition, health & aging · 2025Article
- Systemic inflammation, lifestyle behaviours and dementia: A 10-year follow-up investigation.Brain, behavior, & immunity - health · 2024Article
- Data-driven lifestyle patterns and risk of dementia in older Australian women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Community social support and onset of dementia in older Japanese individuals: a multilevel analysis using the JAGES cohort data.BMJ open · 2021Article
- Social Nesting, Animal Welfare, and Disease Monitoring.Animals : an open access journal from MDPI · 2021Article
- Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males.iScience · 2020Article
- Alzheimer's Disease and Cardiovascular Disease: A Particular Association.Cardiology research and practice · 2020Review
- Vibrating Tail, Digging, Body/Face Interaction, and Lack of Barbering: Sex-Dependent Behavioral Signatures of Social Dysfunction in 3xTg-AD Mice as Compared to Mice with Normal Aging.Journal of Alzheimer's disease : JAD · 2019Article
- Enriched Physical Environment Attenuates Spatial and Social Memory Impairments of Aged Socially Isolated Mice.The international journal of neuropsychopharmacology · 2018Article
- Mediterranean Lifestyle in Relation to Cognitive Health: Results from the HELIAD Study.Nutrients · 2018Article
- An Active Lifestyle Reinforces the Effect of a Healthy Diet on Cognitive Function: A Population-Based Longitudinal Study.Nutrients · 2018Article
- An Action Plan to Face the Challenge of Dementia: INTERNATIONAL STATEMENT ON DEMENTIA from IAP for Health.The journal of prevention of Alzheimer's disease · 2018Article
- Integrative Analysis to Identify Common Genetic Markers of Metabolic Syndrome, Dementia, and Diabetes.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Is Cancer Protective for Subsequent Alzheimer's Disease Risk? Evidence From the Utah Population Database.The journals of gerontology. Series B, Psychological sciences and social sciences · 2017Article
- TheAlzheimer's & dementia (New York, N. Y.) · 2017Article
- Evaluation of Amyloid Protective Factors and Alzheimer Disease Neurodegeneration Protective Factors in Elderly Individuals.JAMA neurology · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
objectivesTo identify distinct behavioral patterns of diet, exercise, social interaction, church attendance, alcohol consumption, and smoking and to examine their association with subsequent dementia risk.
designLongitudinal, population-based dementia study.
settingRural county in northern Utah, at-home evaluations.
participantsTwo thousand four hundred ninety-one participants without dementia (51% male, average age 73.0 ± 5,7; average education 13.7 ± 4.1 years) initially reported no problems in activities of daily living and no stroke or head injury within the past 5 years. MEASUREMENTS: Six dichotomized lifestyle behaviors were examined (diet: high ≥ median on the Dietary Approaches to Stop Hypertension scale; exercise: ≥5 h/wk of light activity and at least occasional moderate to vigorous activity; church attendance: attending church services at least weekly; social Interaction: spending time with family and friends at least twice weekly; alcohol: currently drinking alcoholic beverages ≥ 2 times/wk; nonsmoker: no current use or fewer than 100 cigarettes ever). Latent class analysis (LCA) was used to identify patterns among these behaviors. Proportional hazards regression modeled time to dementia onset as a function of behavioral class, age, sex, education, and apolipoprotein E status. Follow-up averaged 6.3 ± 5.3 years, during which 278 cases of incident dementia (200 Alzheimer's disease (AD)) were diagnosed.
resultsLCA identified four distinct lifestyle classes. Unhealthy-religious (UH-R; 11.5%), unhealthy-nonreligious (UH-NR; 10.5%), healthy-moderately religious (H-MR; 38.5%), and healthy-very religious (H-VR; 39.5%). UH-NR (hazard ratio (HR) = 0.54, P = .028), H-MR (HR = 0.56, P = .003), and H-VR (HR = 0.58, P = .005) had significantly lower dementia risk than UH-R. Results were comparable for AD, except that UH-NR was less definitive.
conclusionFunctionally independent older adults appear to cluster into subpopulations with distinct patterns of lifestyle behaviors with different levels of risk for subsequent dementia and AD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.