ArticleVeterinary research2012
Cell-mediated and humoral immune responses in pigs following primary and challenge-exposure to Lawsonia intracellularis.
Article in Veterinary research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Article
- Vaccination against Lawsonia intracellularis reduced tail-biting related behaviors in a commercial pig herd.Porcine health management · 2026Article
- A low-endotoxic Salmonella vector with dual bacterial-host promoter expression of Lawsonia intracellularis antigens elicits protective immunity in a murine model.Veterinary research · 2026Article
- Immune Response of Pigs Vaccinated Against Proliferative Enteropathy and Co-Infected withAnimals : an open access journal from MDPI · 2025Article
- First molecular detection ofOne health (Amsterdam, Netherlands) · 2025Article
- Porcine proliferative enteropathy: overview of disease dynamics and non-antibiotic alternatives for prevention and control strategies.Frontiers in veterinary science · 2025Review
- Article
- A review of CD4Veterinary immunology and immunopathology · 2024Review
- Epidemiology Tools to Evaluate the Control of Proliferative Enteropathy in Commercial Pig Herds.Animals : an open access journal from MDPI · 2024Article
- Co-Formulation of Recombinant Porcine IL-18 Enhances the Onset of Immune Response in a NewVaccines · 2023Article
- The Effectiveness of Commercial Vaccination againstVeterinary sciences · 2022Review
- Experimental infection of high health pigs with porcine circovirus type 2 (PCV2) andFrontiers in veterinary science · 2022Article
- Review of methods for the detection ofJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Review
- Differences in the relative counts of peripheral blood lymphocyte subsets in various age groups of pigs.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2020Article
- An attenuatedJournal of veterinary science · 2019Article
- Low CD4/CD8 ratio in classical swine fever postnatal persistent infection generated at 3 weeks after birth.Transboundary and emerging diseases · 2019Article
- Article
- Systemic cytokine response in pigs infected orally with a Lawsonia intracellularis isolate of South Korean origin.The Journal of veterinary medical science · 2018Article
- Review
- Efficient priming of CD4 T cells by Langerin-expressing dendritic cells targeted with porcine epidemic diarrhea virus spike protein domains in pigs.Virus research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate immune responses upon re-infection with Lawsonia intracellularis, local and peripheral humoral and cell-mediated immune responses to primary and challenge inoculations were studied in 22 pigs. Pigs were orally inoculated with virulent L. intracellularis at the age of 5-6 weeks, treated with antibiotics and challenged with a re-inoculation (RE) at the age of 12 weeks. Treatment control (TC) pigs received only the primary inoculation and challenge control (CC) pigs received only the secondary inoculation at 12 weeks of age. Following this regimen, all RE pigs were protected against the re-infection as defined by reduced colonisation and pathology of intestinal mucosa, absence of bacterial shedding and without increase in serum acute phase protein response. In the protected RE pigs, serum IgG responses were variable with both high and low responders. Serum IgA responses were not boosted by the re-inoculation, since identical intestinal IgA responses developed in response to the inoculation in both the susceptible CC pigs and the protected RE pigs. A memory recall cell-mediated immune response developed in RE pigs which was significantly stronger compared to the primary response in age-matched CC pigs as assessed by whole blood IFN-γ assay and by calculation of IFN-γ integrated median fluorescence intensity (iMFI) after flow cytometry. The major IFN-γ producing cells were identified as CD8+ and CD4+CD8+ double positive lymphocytes. The results indicate that cell-mediated immune responses are likely mediators of protective immunity against L. intracellularis, with CD8+ effector cells and CD4+CD8+ double positive memory T cells as main contributors to the antigen-specific IFN-γ production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.