ArticleVeterinary research2012
Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice.
Article in Veterinary research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Neutrophil extracellular traps and parasite load are associated with dermal matrix remodeling in Leishmania braziliensis infection.Revista da Sociedade Brasileira de Medicina Tropical · 2026Article
- Antigen recognition reinforces regulatory T cell mediated Leishmania major persistence.Nature communications · 2023Article
- Novel Insights IntoFrontiers in cellular and infection microbiology · 2022Article
- Modulation of Cytokines and Extracellular Matrix Proteins Expression byFrontiers in microbiology · 2020Article
- Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases.Clinical microbiology reviews · 2019Review
- A comparative analysis of secreted protein disulfide isomerases from the tropical co-endemic parasites Schistosoma mansoni and Leishmania major.Scientific reports · 2019Article
- Leishmania amazonensis resistance in murine macrophages: Analysis of possible mechanisms.PloS one · 2019Article
- Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism.Frontiers in immunology · 2019Article
- Leishmaniasis and glycosaminoglycans: a future therapeutic strategy?Parasites & vectors · 2018Review
- Morphophysiological changes in the splenic extracellular matrix of Leishmania infantum-naturally infected dogs is associated with alterations in lymphoid niches and the CD4+ T cell frequency in spleens.PLoS neglected tropical diseases · 2018Article
- The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis.Parasites & vectors · 2016Review
- The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis.Trends in parasitology · 2014Review
- Large-scale investigation of Leishmania interaction networks with host extracellular matrix by surface plasmon resonance imaging.Infection and immunity · 2014Article
- Leishmania braziliensis and Leishmania amazonensis amastigote extracts differ in their enhancement effect on Leishmania infection when injected intradermally.BMC research notes · 2014Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leishmania is inoculated, by the bite of an infected sandfly, into the skin of the host, where the promastigotes are phagocyted by dermal macrophages. The dermal region comprises cells and abundant extracellular matrix. Studies show that matrix metalloproteinases play an important role in host defense responses against pathogens in mammals and that their activities lead to the production of antimicrobial peptides. The aim of this study is to evaluate the changes in the distribution of fibronectin and laminin as well as in the elastic system fibres during the course of infection caused by Leishmania amazonensis in mice with distinct genetic backgrounds of susceptibility to this parasite. The results showed that BALB/c presented an enhancement of fibronectin during the course of infection when compared to their control group while the infected or non-infected C3H.He showed a decrease of this protein at end of the experiment. Laminin, on the other hand, remained unaltered in both strains. Also in both BALB/c and C3H.He mice the elastic and elaunin fibres remained unchanged while the oxytalan fibres decreased along the experiment. Ninety days after the infection C3H.He mice had recovered their capacity to produce oxytalan fibres.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.