ArticleMalaria research and treatment2012
Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts.
Article in Malaria research and treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
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- Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (Antibiotics (Basel, Switzerland) · 2020Review
- Antioxidant, antibacterial and anticancer properties of phytoIET nanobiotechnology · 2017Article
- Article
- Ethnomedicines and anti-parasitic activities of Pakistani medicinal plants against Plasmodia and Leishmania parasites.Annals of clinical microbiology and antimicrobials · 2016Review
- Phytosynthesis of silver nanoparticles using Artemisia marschalliana Sprengel aerial part extract and assessment of their antioxidant, anticancer, and antibacterial properties.International journal of nanomedicine · 2016Article
- Antiplasmodial activity of ethanolic extracts of some selected medicinal plants from the northwest of Iran.Parasitology research · 2013Article
- Evaluation of Effectiveness of Ethanolic Extract of Artemisia aucheri, Individually and in Combination with Chloroquine, on Chloroquine - Sensitive Strain of Plasmodium berghei in Sourian Mice.Iranian journal of public health · 2013Article
- Antimalarial Activity of Hydroalcoholic Root Extract ofJournal of evidence-based integrative medicineArticle
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study is pharmacochemistry of Iranian flora Artemisia sieberi and its antimalarial effects on Plasmodium berghei in vivo. This is the first application of A. sieberi for treatment of murine malaria. A. sieberi were collected at flowering stage from the Khorassan and Semnan provinces of Iran; the aerial parts were air-dried at room temperature and then powdered. The powder was macerated in methanol, filtered with Bokhner hopper and solvent was separated in rotary evaporator. Total herbal extract was subsequently processed for ether and chloroform extracts preparation. The toxicity of herbal extract was assessed on naive NMRI mice with high, average and low doses; then pathophysiological signs were assessed. Finally, the antimalarial efficacy was investigated on two groups of Plasmodium berghei infected mice. Percentage of parasitaemia and pathophysiology were also evaluated. The results of this assessment showed no toxicity even by high concentration of herbal extract. A significant reduction in percentage of parasitaemia was observed; no alterations of hepatosplenomegaly and body weight were indicated in study group. A. sieberi extracts showed antimalarial effects against murine malaria with some efficacies on reducing pathophysiology. However, there is requirement to find the major component of this herbal extract by further studies.
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Registered trials
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