ArticleInternational journal of vascular medicine2012
The importance of velocity acceleration to flow-mediated dilation.
Article in International journal of vascular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Hemadyne: accordion-inspired perfusion for microphysiological systems.Nature communications · 2026Article
- Acute Effects of Combining Weight and Elastic Resistance Exercise on Vascular Function in Older Adults.Geriatrics (Basel, Switzerland) · 2024Article
- High-speed measurement of retinal arterial blood flow in the living human eye with adaptive optics ophthalmoscopy.Optics letters · 2023Article
- Impact of catheterization on shear-mediated arterial dilation in healthy young men.European journal of applied physiology · 2020Article
- Endothelium function dependence of acute changes in pulse wave velocity and flow-mediated slowing.Vascular medicine (London, England) · 2020Article
- Endothelial Cell Biomechanical Responses are Dependent on Both Fluid Shear Stress and Tensile Strain.Cellular and molecular bioengineering · 2019Article
- The impact of upper-limb position on estimated central blood pressure waveforms.Journal of human hypertension · 2019Article
- Rock Climbing for Promoting Physical Activity in Youth.American journal of lifestyle medicineReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The validity of the flow-mediated dilation test has been questioned due to the lack of normalization to the primary stimulus, shear stress. Shear stress can be calculated using Poiseuille's law. However, little attention has been given to the most appropriate blood velocity parameter(s) for calculating shear stress. The pulsatile nature of blood flow exposes the endothelial cells to two distinct shear stimuli during the cardiac cycle: a large rate of change in shear at the onset of flow (velocity acceleration), followed by a steady component. The parameter typically entered into the Poiseuille's law equation to determine shear stress is time-averaged blood velocity, with no regard for flow pulsatility. This paper will discuss (1) the limitations of using Posieuille's law to estimate shear stress and (2) the importance of the velocity profile-with emphasis on velocity acceleration-to endothelial function and vascular tone.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.