ArticleJournal of allergy2012
Mechanisms of remodeling in asthmatic airways.
Article in Journal of allergy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exposure to cement industry emissions and respiratory health outcomes: a global systematic review and meta-analysis from 2000 to 2025.Frontiers in public health · 2026Pooled it
- Risk Factors Associated with Irreversible Airway Obstruction in Asthma: A Systematic Review and Meta-Analysis.BioMed research international · 2016Pooled it
- Efficacy ofNutrients · 2018Trial
- Paradoxical enrichment ofFrontiers in immunology · 2026Article
- Prognostic Predictors of Bronchial Thermoplasty for Symptom Control in Severe Asthma.Journal of asthma and allergy · 2026Article
- Aging and lung diseases: Unraveling mechanisms and therapeutic targets.Chinese medical journal pulmonary and critical care medicine · 2025Review
- Oxidative Stress and Risk Factors in Adult Patients with Bronchial Asthma: A Clinical Analysis of Representative Biomarkers.Journal of clinical medicine · 2025Article
- Progranulin derivative attenuates lung neutrophilic infiltration from diesel exhaust particle exposure.Allergy · 2025Article
- The role of matrix metalloproteinase-2 and miR-196a2 in bronchial asthma pathogenesis and diagnosis.Heliyon · 2024Article
- The Association between Vitamin D, Interleukin-4, and Interleukin-10 Levels and CD23+ Expression with Bronchial Asthma in Stunted Children.Biomedicines · 2023Article
- Article
- Anti-inflammatory, immunomodulatory and anti-oxidant effects ofIranian journal of basic medical sciences · 2023Review
- Understanding fibroblast-immune cell interactionsFrontiers in immunology · 2023Review
- Oxidative stress in patients with asthma and its relation to uncontrolled asthma.Journal of clinical laboratory analysis · 2022Article
- A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype.Asthma research and practice · 2022Article
- The Role of IgE in Upper and Lower Airway Disease: More Than Just Allergy!Clinical reviews in allergy & immunology · 2022Review
- Association Between Medication Adherence and Risk of COPD in Adult Asthma Patients: A Retrospective Cohort Study in Canada.Clinical epidemiology · 2022Article
- An update on extra-oral bitter taste receptors.Journal of translational medicine · 2021Review
- Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3.The Journal of allergy and clinical immunology · 2021Article
- Mitochondrial ATP-Sensitive K+ Channel Opening Increased the Airway Smooth Muscle Cell Proliferation by Activating the PI3K/AKT Signaling Pathway in a Rat Model of Asthma.Canadian respiratory journal · 2021Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Asthma is a chronic inflammatory airway disorder characterized by airway hyperresponsiveness and reversible airflow obstruction. Subgroups of asthma patients develop airflow obstruction that is irreversible or only partially reversible and experience an accelerated rate of lung function decline. The structural changes in the airways of these patients are referred to as airway remodeling. All elements of the airway wall are involved, and remodeled airway wall thickness is substantially increased compared to normal control airways. Airway remodeling is thought to contribute to the subphenotypes of irreversible airflow obstruction and airway hyperresponsiveness, and it has been associated with increased disease severity. Reversal of remodeling is therefore of paramount therapeutic importance, and mechanisms responsible for airway remodeling are feasible therapeutic targets for asthma treatment. This paper will focus on our current understanding of the mechanisms of airway remodeling in asthma and potential targets for future intervention.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.