ArticleExperimental diabetes research2012
Time-dependent alterations in rat macrovessels with type 1 diabetes.
Article in Experimental diabetes research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Prevalence and incidence of diabetic peripheral neuropathy in Latin America and the Caribbean: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Sex differences in arterial stiffness in a rat model of type 1 diabetes.Frontiers in physiology · 2026Article
- In Vivo Effects of Quercetin in Association with Moderate Exercise Training in Improving Streptozotocin-Induced Aortic Tissue Injuries.Molecules (Basel, Switzerland) · 2015Article
- Urethral striated muscle and extracellular matrix morphological characteristics among mildly diabetic pregnant rats: translational approach.International urogynecology journal · 2014Article
- Prevalence of diabetic peripheral neuropathy in Iran: a systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2014Article
- Angiotensin II receptor blocker telmisartan attenuates aortic stiffening and remodelling in STZ-diabetic rats.Diabetology & metabolic syndrome · 2014Article
- Roles of polyuria and hyperglycemia in bladder dysfunction in diabetes.The Journal of urology · 2013Article
- Organ-based response to exercise in type 1 diabetes.ISRN endocrinology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular complications are associated with the progressive severity of diabetes, resulting in significant morbidity and mortality. This study quantifies functional vascular parameters and macrovascular structure in a rat model of type 1 diabetes. While there was no difference in the systemic arterial elastance (Ea) with 50 days of diabetes, changes were noted in the aorta and femoral artery including increased tunica media extracellular matrix content, decreased width of both the media and individual smooth muscle cell layers, and increased incidence of damaged mitochondria. Extracellular matrix proteins and elastin levels were significantly greater in the aorta of diabetic animals. These differences correlated with diminished matrix metalloprotease activity in the aorta of the diabetic animals. In conclusion, diabetes significantly altered the structure and ultrastructure of the aorta and femoral artery before systemic changes in arterial elastance could be detected.
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Registered trials
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