ArticleEndocrinology2012
Developmental increase in kisspeptin-54 release in vivo is independent of the pubertal increase in estradiol in female rhesus monkeys (Macaca mulatta).
Article in Endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Developmental sex differences in the peri-pubertal pattern of hypothalamic reproductive gene expression, including Kiss1 and Tac2, may contribute to sex differences in puberty onset.Molecular and cellular endocrinology · 2022Article
- The mechanism underlying the pubertal increase in pulsatile GnRH release in primates.Journal of neuroendocrinology · 2022Review
- Neuroendocrine mechanisms of puberty in non-human primates.Current opinion in endocrine and metabolic research · 2020Article
- Does the KNDy Model for the Control of Gonadotropin-Releasing Hormone Pulses Apply to Monkeys and Humans?Seminars in reproductive medicine · 2019Review
- Role of Kisspeptin and NKB in Puberty in Nonhuman Primates: Sex Differences.Seminars in reproductive medicine · 2019Review
- Role of Kisspeptin and Neurokinin B Signaling in Male Rhesus Monkey Puberty.Endocrinology · 2018Article
- Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates.Frontiers in endocrinology · 2018Review
- Kisspeptin and Neurokinin B Signaling Network Underlies the Pubertal Increase in GnRH Release in Female Rhesus Monkeys.Endocrinology · 2017Article
- Reducing adsorption to improve recovery and in vivo detection of neuropeptides by microdialysis with LC-MS.Analytical chemistry · 2015Article
- Neuroendocrine control of the onset of puberty.Frontiers in neuroendocrinology · 2015Review
- Acute Influences of Bisphenol A Exposure on Hypothalamic Release of Gonadotropin-Releasing Hormone and Kisspeptin in Female Rhesus Monkeys.Endocrinology · 2015Article
- Prolonged infusion of estradiol benzoate into the stalk median eminence stimulates release of GnRH and kisspeptin in ovariectomized female rhesus macaques.Endocrinology · 2015Article
- Daily successive changes in reproductive gene expression and neuronal activation in the brains of pubertal female mice.Molecular and cellular endocrinology · 2015Article
- Emerging concepts on the epigenetic and transcriptional regulation of the Kiss1 gene.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Review
- Article
- Ovarian regulation of kisspeptin neurones in the arcuate nucleus of the rhesus monkey (macaca mulatta).Journal of neuroendocrinology · 2013Article
- Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Development and Aging of the Kisspeptin-GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function?Frontiers in endocrinology · 2013Article
- Kisspeptin and puberty in mammals.Advances in experimental medicine and biology · 2013Review
- Interactions between kisspeptins and neurokinin B.Advances in experimental medicine and biology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Kisspeptin (KP) signaling has been proposed as an important regulator in the mechanism of puberty. In this study, to determine the role of KP in puberty, we assessed the in vivo release pattern of KP-54 from the basal hypothalamus/stalk-median eminence in prepubertal and pubertal ovarian-intact female rhesus monkeys. We found that there was a developmental increase in mean KP-54 release, pulse frequency, and pulse amplitude, which is parallel to the developmental changes in GnRH release that we previously reported. Moreover, a nocturnal increase in KP-54 release becomes prominent after the onset of puberty. Because the pubertal increase in GnRH release occurs independent of the pubertal increase in circulating gonadal steroids, we further examined whether ovariectomy (OVX) modifies the release pattern of KP-54. Results show that OVX in pubertal monkeys enhanced mean KP-54 release and pulse amplitude but not pulse frequency, whereas OVX did not alter the release pattern of KP-54 in prepubertal monkeys. Estradiol replacement in OVX pubertal monkeys suppressed mean KP-54 release and pulse amplitude but not pulse frequency. Estradiol replacement in OVX prepubertal monkeys did not alter the KP-54 release pattern. Collectively these results suggest that the pubertal increase in KP release occurs independent of the pubertal increase in circulating estradiol. Nevertheless, the pubertal increase in KP release is not likely responsible for the initiation of the pubertal increase in GnRH release. Rather, after puberty onset, the increase in KP release contributes to further increase GnRH release during the progression of puberty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.