Evidence map›Paper›PMID 22315269›Full record

ReviewChest2012

Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Walter Ageno, Alexander S Gallus, Ann Wittkowsky, Mark Crowther, Elaine M Hylek, Gualtiero Palareti

2 registry-linked trialsOpen access · bronzeAbstract readComparative StudyReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chest, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 529 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
529citing papers in PubMed, 19 pooled it
100.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03647254 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Effectivity of a Joint Didactic Intervention by School for Patients on Inappropriate Control Prothrombin Time Anticoagulated Patients. Protocol for Developing a Randomized and Controlled Clinical Trial

TypeinterventionalSponsorFrancisco Javier Navarro MoyaRan2018 to 2021Enrolled1ConditionsHealth Education, Patient Education as Topic, Blood Coagulation TestsArmsPatient education group
NCT04569279 phase3completednot on this mapstarted 2017, after this paper: background citation

Rivaroxaban Compared to Warfarin for Treatment of Cerebral Venous Thrombosis: a Randomized Controlled Trial

TypeinterventionalSponsorDamascus UniversityRan2017 to 2020Enrolled71ConditionsCerebral Vein ThrombosisArmsRivaroxaban, Warfarin
3 · Its place in the literature

Who cites it

529 citing papers in PubMed, 19 syntheses or guidelines pooled it, 1,489 citations in OpenAlex.

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  17. A meta-analysis on anticoagulation after vascular trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020
    Pooled it
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  19. Anticoagulant treatment for subsegmental pulmonary embolism.The Cochrane database of systematic reviews · 2020
    Pooled it
  20. Trial

469 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 4 countries.

Walter AgenoUniversity of Insubria, Varese, Italy. Electronic address: walter.ageno@uninsubria.it.
Alexander S GallusFlinders University, Adelaide, SA, Australia.
Ann WittkowskyUniversity of Washington, Seattle, WA, Canada.
Mark CrowtherMcMaster University, St. Joseph's Hospital, Hamilton, ON, Canada.
Elaine M HylekBoston University School of Medicine, Boston, MA.
Gualtiero PalaretiUniversity Hospital S. Orsola-Malpighi, Bologna, Italy.
Boston University · USFlinders University · AUPoliclinico S.Orsola-Malpighi · ITSt. Joseph’s Healthcare Hamilton · CAUniversity of Insubria · ITUniversity of Washington · US

Funding

Antithrombotic Therapy and Prevention of Thrombosis: ACCP Evidence-Based ClinicalR13HL104758 · NHLBI · AMERICAN COLLEGE OF CHEST PHYSICIANS · PI LEWIS, SANDRA ZELMAN · 2010 to 2010
$11k
NHLBI NIH HHS R13 HL104758
6 · The paper itself

Abstract

backgroundThe objective of this article is to summarize the published literature concerning the pharmacokinetics and pharmacodynamics of oral anticoagulant drugs that are currently available for clinical use and other aspects related to their management.

methodsWe carried out a standard review of published articles focusing on the laboratory and clinical characteristics of the vitamin K antagonists; the direct thrombin inhibitor, dabigatran etexilate; and the direct factor Xa inhibitor, rivaroxaban

resultsThe antithrombotic effect of each oral anticoagulant drug, the interactions, and the monitoring of anticoagulation intensity are described in detail and discussed without providing specific recommendations. Moreover, we describe and discuss the clinical applications and optimal dosages of oral anticoagulant therapies, practical issues related to their initiation and monitoring, adverse events such as bleeding and other potential side effects, and available strategies for reversal.

conclusionsThere is a large amount of evidence on laboratory and clinical characteristics of vitamin K antagonists. A growing body of evidence is becoming available on the first new oral anticoagulant drugs available for clinical use, dabigatran and rivaroxaban.

Indexed as

Evidence-Based MedicinePractice Guidelines as TopicSocieties, MedicalAdministration, OralAnticoagulantsAntithrombinsBenzimidazolesDabigatranDose-Response Relationship, DrugFactor XaFactor Xa InhibitorsHumansMorpholinesPyridinesRivaroxabanThiophenesAnticoagulantsAntithrombinsBenzimidazolesDabigatranFactor XaFactor Xa InhibitorsMorpholinesPyridinesRivaroxabanThiophenesVitamin K

Identifiers

PMID22315269
PMCPMC3278051
OpenAlexW1998354077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.