Evidence map›Paper›PMID 22315268›Full record

GuidelineChest2012

Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Clive Kearon, Elie A Akl, Anthony J Comerota, Paolo Prandoni, Henri Bounameaux, Samuel Z Goldhaber, Michael E Nelson, Philip S Wells, Michael K Gould, Francesco Dentali and 2 more

Erratum issued 9 registry-linked trialsOpen access · bronzeAbstract readComparative StudyPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Chest, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 9 registered trials, which are not on this map. Cited by 1,115 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,115citing papers in PubMed, 13 pooled it
547.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02155491 completednot on this mapstarted 2014, after this paper: background citation

Global Anticoagulant Registry in the Field Observing Treatment and Outcomes in Patients With Treated Acute Venous Thromboembolic Events in the Real World

Typeobservational_patient_registrySponsorThrombosis Research InstituteRan2014 to 2020Enrolled10,679ConditionsVenous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolism
NCT02238639 nacompletednot on this mapstarted 2014, after this paper: background citation

Efficacy and Safety of an Active Strategy for the Diagnosis and Treatment of Acute Pulmonary Embolism (PE) in Patients With Unexplained Exacerbations of Chronic Obstructive Pulmonary Disease (COPD): a Randomized Clinical Trial

TypeinterventionalSponsorMinistry of Health, SpainRan2014 to 2020Enrolled746ConditionsPulmonary Embolism, Chronic Obstructive Pulmonary DiseaseArmsDiagnostic and therapeutic strategy: Highly sensitive D-dimer testing and, if positive, multidetector computed tomographic pulmonary angiography (MDCT).
NCT02645682 naunknown statusnot on this mapstarted 2016, after this paper: background citation

The Effects of Anti-infective Central Venous Catheter(CVC) on Catheter-related Bloodstream Infection(CRBSI) in Critical Care Patients: a Multiple-center, Randomized, Control Study

TypeinterventionalSponsorWest China HospitalRan2016 to 2018Enrolled1,818ConditionsCritical IllnessArmsanti-infection CVC, normal CVC
NCT02758574 nacompletednot on this mapstarted 2016, after this paper: background citation

Comparison of Standard Catheter Directed Thrombolysis vs. Ultrasound Assisted Thrombolysis for Patients With Acute Submassive Pulmonary Embolism

TypeinterventionalSponsorUniversity of PittsburghRan2016 to 2021Enrolled77ConditionsPulmonary EmbolismArmsCDT without ultrasound acceleration, CDT with ultrasound acceleration
NCT03299296 phase3unknown statusnot on this mapstarted 2017, after this paper: background citation

Thromboprophylaxis in Patients Undergoing Orthopedic Surgeries; Focus on Cost-effective Analysis and Safety Comparison Between Rivaroxaban and Enoxaparin

TypeinterventionalSponsorAhmed AbdelMoneim Hassan AliRan2017 to 2018Enrolled100ConditionsThromboses, Deep Vein, Surgery--ComplicationsArmsRivaroxaban 10 Milligrams, Enoxaparin 40 Milligrams/0.4 Milliliters Prefilled Syringe
NCT03389971 nacompletednot on this mapstarted 2017, after this paper: background citation

ULTRAsound-assisted Catheter vs. STAndaRd Catheter Thrombolysis for Submassive Pulmonary Embolism

TypeinterventionalSponsorPiedmont HealthcareRan2017 to 2020Enrolled10ConditionsSubmassive Pulmonary EmbolismArmscatheter-directed thrombolysis
NCT06341010 recruitingnot on this mapstarted 2024, after this paper: background citation

The Role of Angiojet Rheolytic Thrombectomy in The Management of Iliofemoral Deep Venous Thrombosis

TypeobservationalSponsorAbdelrahman Ibrahim Sayed Mohamed AbdallaRan2024 to 2026Enrolled25ConditionsIliofemoral Deep Vein ThrombosisArmsAngiojet Rheolytic Thrombectomy in The Management of Iliofemoral Deep Venous Thrombosis
NCT06393868 phase3recruitingnot on this mapstarted 2024, after this paper: background citation

Reducing Gastrointestinal Bleeding With Proton Pump Inhibitor Therapy in Acute Venous Thromboembolism: Pilot Randomized Study (RADIANT Study)

TypeinterventionalSponsorOttawa Hospital Research InstituteRan2024 to 2028Enrolled360ConditionsVenous Thromboembolism, Gastro Intestinal Bleeding, Blood ClotArmsOmeprazole 20 mg Oral Tablet, Placebo
NCT06958588 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Pulsed Electromagnetic Field Therapy (PEMF) Compared to Conventional Mechanical Prophylaxis for Venous Thromboembolism Prophylaxis in Patients in the Intensive Care Unit (ICU)

TypeinterventionalSponsorScience Valley Research InstituteRan2025 to 2026Enrolled50ConditionsVenous Thromboembolism (VTE), Intensive Care Medicine, Venous ThromboembolismArmsExperimental: Hyperslim, Active Comparator #1
3 · Its place in the literature

Who cites it

1,115 citing papers in PubMed, 13 syntheses or guidelines pooled it, 6,117 citations in OpenAlex.

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  16. Assessment of Cavitation From DEFINITY and DEFINITY RT.Ultrasound in medicine & biology · 2026
    Article
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  19. Review
  20. Observational

1,055 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 4 countries.

Clive KearonDepartment of Medicine and Clinical Epidemiology and Biostatistics, Michael De Groote School of Medicine, McMaster University, Hamilton, ON, Canada.
Elie A AklDepartment of Medicine, Family Medicine, and Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY. Electronic address: elieakl@buffalo.edu.
Anthony J ComerotaDepartment of Surgery, Jobst Vascular Center, Toledo, OH.
Paolo PrandoniDepartment of Cardiothoracic and Vascular Sciences, University of Padua, Padua, Italy.
Henri BounameauxDepartment of Medical Specialties, University Hospitals of Geneva, Geneva, Switzerland.
Samuel Z GoldhaberDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Michael E NelsonDepartment of Medicine, Shawnee Mission Medical Center, Shawnee Mission, KS.
Philip S WellsDepartment of Medicine, University of Ottawa, Ottawa, ON, Canada.
Michael K GouldDepartment of Medicine and Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Francesco DentaliDepartment of Medicine, University of Insubria, Varese, Italy.
Mark CrowtherDepartment of Medicine, Michael De Groote School of Medicine, McMaster University, Hamilton, ON, Canada.
Susan R KahnDepartment of Medicine and Clinical Epidemiology and Biostatistics, McGill University, Montreal, QC, Canada.
McMaster University · CAHarvard University · USMcGill University · CAShawnee Mission Medical Center · USUniversity at Buffalo, State University of New York · USUniversity Hospital of Geneva · CHUniversity of Insubria · ITUniversity of Ottawa · CAUniversity of Padua · ITUniversity of Southern California · US

Funding

Antithrombotic Therapy and Prevention of Thrombosis: ACCP Evidence-Based ClinicalR13HL104758 · NHLBI · AMERICAN COLLEGE OF CHEST PHYSICIANS · PI LEWIS, SANDRA ZELMAN · 2010 to 2010
$11k
NHLBI NIH HHS R13 HL104758
6 · The paper itself

Abstract

backgroundThis article addresses the treatment of VTE disease.

methodsWe generated strong (Grade 1) and weak (Grade 2) recommendations based on high-quality (Grade A), moderate-quality (Grade B), and low-quality (Grade C) evidence.

resultsFor acute DVT or pulmonary embolism (PE), we recommend initial parenteral anticoagulant therapy (Grade 1B) or anticoagulation with rivaroxaban. We suggest low-molecular-weight heparin (LMWH) or fondaparinux over IV unfractionated heparin (Grade 2C) or subcutaneous unfractionated heparin (Grade 2B). We suggest thrombolytic therapy for PE with hypotension (Grade 2C). For proximal DVT or PE, we recommend treatment of 3 months over shorter periods (Grade 1B). For a first proximal DVT or PE that is provoked by surgery or by a nonsurgical transient risk factor, we recommend 3 months of therapy (Grade 1B; Grade 2B if provoked by a nonsurgical risk factor and low or moderate bleeding risk); that is unprovoked, we suggest extended therapy if bleeding risk is low or moderate (Grade 2B) and recommend 3 months of therapy if bleeding risk is high (Grade 1B); and that is associated with active cancer, we recommend extended therapy (Grade 1B; Grade 2B if high bleeding risk) and suggest LMWH over vitamin K antagonists (Grade 2B). We suggest vitamin K antagonists or LMWH over dabigatran or rivaroxaban (Grade 2B). We suggest compression stockings to prevent the postthrombotic syndrome (Grade 2B). For extensive superficial vein thrombosis, we suggest prophylactic-dose fondaparinux or LMWH over no anticoagulation (Grade 2B), and suggest fondaparinux over LMWH (Grade 2C).

conclusionStrong recommendations apply to most patients, whereas weak recommendations are sensitive to differences among patients, including their preferences.

Indexed as

Evidence-Based MedicineSocieties, MedicalAdministration, OralAnticoagulantsDiagnostic ImagingDrug Administration ScheduleFibrinolytic AgentsFondaparinuxHemorrhageHeparin, Low-Molecular-WeightHumansInfusions, IntravenousInternational Normalized RatioLong-Term CarePolysaccharidesPulmonary EmbolismAnticoagulantsFibrinolytic AgentsFondaparinuxHeparin, Low-Molecular-WeightPolysaccharidesVitamin K

Identifiers

PMID22315268
PMCPMC3278049
OpenAlexW2131099415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 3 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.