Evidence map›Paper›PMID 22315262›Full record

SynthesisChest2012

Patient values and preferences in decision making for antithrombotic therapy: a systematic review: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Samantha MacLean, Sohail Mulla, Elie A Akl, Milosz Jankowski, Per Olav Vandvik, Shanil Ebrahim, Shelley McLeod, Neera Bhatnagar, Gordon H Guyatt

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Chest, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07168005 (Does an Informative Video Reduce Anxiety and Pain Before LMWH Treatment Postpartum? - A Randomized Controlled Trial), which is not on this map. Cited by 105 papers, 26 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 26 pooled it
103.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07168005 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Does an Informative Video Reduce Anxiety and Pain Before LMWH Treatment Postpartum? - A Randomized Controlled Trial

TypeinterventionalSponsorWolfson Medical CenterRan2025 to 2027Enrolled160ConditionsVenous Thromboembolism (VTE), Postpartum Care, AnxietyArmsInformative Video on LMWH, Standard Verbal Explanation
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 26 syntheses or guidelines pooled it, 255 citations in OpenAlex.

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  8. Women's Values and Preferences Regarding Osteoporosis Treatments: A Systematic Review.The Journal of clinical endocrinology and metabolism · 2019
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Samantha MacLeanDepartment of Biostatistics and Clinical Epidemiology, McMaster University, Hamilton, ON, Canada. Electronic address: macleast@mcmaster.ca.
Sohail MullaDepartment of Biostatistics and Clinical Epidemiology, McMaster University, Hamilton, ON, Canada.
Elie A AklDepartment of Biostatistics and Clinical Epidemiology, McMaster University, Hamilton, ON, Canada; Department of Medicine, State University of New York at Buffalo, Buffalo, NY.
Milosz JankowskiDepartment of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.
Per Olav VandvikNorwegian Knowledge Centre for the Health Services and Department of Medicine Gjøvik, Innlandet Hospital Trust, Gjøvik, Norway.
Shanil EbrahimDepartment of Biostatistics and Clinical Epidemiology, McMaster University, Hamilton, ON, Canada.
Shelley McLeodDivision of Emergency Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada.
Neera BhatnagarDepartment of Health Sciences Library, McMaster University, Hamilton, ON, Canada.
Gordon H GuyattDepartment of Biostatistics and Clinical Epidemiology, McMaster University, Hamilton, ON, Canada.
McMaster University · CAInnlandet Hospital Trust · NOJagiellonian University · PLUniversity at Buffalo, State University of New York · USWestern University · CA

Funding

Antithrombotic Therapy and Prevention of Thrombosis: ACCP Evidence-Based ClinicalR13HL104758 · NHLBI · AMERICAN COLLEGE OF CHEST PHYSICIANS · PI LEWIS, SANDRA ZELMAN · 2010 to 2010
$11k
NHLBI NIH HHS R13 HL104758
6 · The paper itself

Abstract

backgroundDevelopment of clinical practice guidelines involves making trade-offs between desirable and undesirable consequences of alternative management strategies. Although the relative value of health states to patients should provide the basis for these trade-offs, few guidelines have systematically summarized the relevant evidence. We conducted a systematic review relating to values and preferences of patients considering antithrombotic therapy.

methodsWe included studies examining patient preferences for alternative approaches to antithrombotic prophylaxis and studies that examined, in the context of antithrombotic prophylaxis or treatment, how patients value alternative health states and experiences with treatment. We conducted a systematic search and compiled structured summaries of the results. Steps in the process that involved judgment were conducted in duplicate.

resultsWe identified 48 eligible studies. Sixteen dealt with atrial fibrillation, five with VTE, four with stroke or myocardial infarction prophylaxis, six with thrombolysis in acute stroke or myocardial infarction, and 17 with burden of antithrombotic treatment.

conclusionPatient values and preferences regarding thromboprophylaxis treatment appear to be highly variable. Participant responses may depend on their prior experience with the treatments or health outcomes considered as well as on the methods used for preference elicitation. It should be standard for clinical practice guidelines to conduct systematic reviews of patient values and preferences in the specific content area.

Indexed as

Decision MakingEvidence-Based MedicinePatient ParticipationPatient PreferencePractice Guidelines as TopicSocial ValuesAtrial FibrillationCost of IllnessFibrinolytic AgentsHumansMyocardial InfarctionPatient SatisfactionSocieties, MedicalStrokeThrombolytic TherapyThrombosisFibrinolytic Agents

Identifiers

PMID22315262
PMCPMC3278050
OpenAlexW2111192628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.