ArticleThe Journal of comparative neurology2012
Glial responses after chorda tympani nerve injury.
Article in The Journal of comparative neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Retaining Chorda Tympani Nerve Integrity During Cochlear Implant Surgery.Chinese medical journal · 2015Trial
- Nerve Injury-Induced Immune Responses in the Taste Bud Target Field.International journal of molecular sciences · 2026Article
- Chemogenetic suppression of NST GABA neurons reveals inhibition of behavioral responses to sucrose and quinine.Physiology & behavior · 2025Article
- Maternal diet during early gestation influences postnatal taste activity-dependent pruning by microglia.The Journal of experimental medicine · 2023Article
- Regulation of Rostral Nucleus of the Solitary Tract Responses to Afferent Input by A-type K+ Current.Neuroscience · 2022Article
- Immune responses in the injured olfactory and gustatory systems: a role in olfactory receptor neuron and taste bud regeneration?Chemical senses · 2022Review
- Kv4 channel expression and kinetics in GABAergic and non-GABAergic rNST neurons.Journal of neurophysiology · 2020Article
- Astrocytes in the nucleus of the solitary tract: Contributions to neural circuits controlling physiology.Physiology & behavior · 2020Review
- Astrocytic response to neural injury is larger during development than in adulthood and is not predicated upon the presence of microglia.Brain, behavior, & immunity - health · 2020Article
- Neurons with diverse phenotypes project from the caudal to the rostral nucleus of the solitary tract.The Journal of comparative neurology · 2018Article
- Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury.The Journal of experimental medicine · 2018Article
- Impact of recurrent laryngeal nerve lesion on oropharyngeal muscle activity and sensorimotor integration in an infant pig model.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Transcriptomes and neurotransmitter profiles of classes of gustatory and somatosensory neurons in the geniculate ganglion.Nature communications · 2017Article
- Microglia density decreases in the rat rostral nucleus of the solitary tract across development and increases in an age-dependent manner following denervation.Neuroscience · 2017Article
- Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice.The Journal of comparative neurology · 2017Article
- Inhibitory modulation of optogenetically identified neuron subtypes in the rostral solitary nucleus.Journal of neurophysiology · 2016Article
- P2X2 Receptor Terminal Field Demarcates a "Transition Zone" for Gustatory and Mechanosensory Processing in the Mouse Nucleus Tractus Solitarius.Chemical senses · 2016Article
- Effects of high-fat diet and gastric bypass on neurons in the caudal solitary nucleus.Physiology & behavior · 2015Article
- Nucleus of the solitary tract in the C57BL/6J mouse: Subnuclear parcellation, chorda tympani nerve projections, and brainstem connections.The Journal of comparative neurology · 2014Article
- Birthdating of myenteric neuron subtypes in the small intestine of the mouse.The Journal of comparative neurology · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The chorda tympani (CT) nerve innervates lingual taste buds and is susceptible to damage during dental and inner ear procedures. Interruption of the CT results in a disappearance of taste buds, which can be accompanied by taste disturbances. Because the CT usually regenerates to reinnervate taste buds successfully within a few weeks, a persistence of taste disturbances may indicate alterations in central nervous function. Peripheral injury to other sensory nerves leads to glial responses at central terminals, which actively contribute to abnormal sensations arising from nerve damage. Therefore, the current study examined microglial and astrocytic responses in the first central gustatory relay, the nucleus of the solitary tract (nTS), after transection of the CT. Damage to the CT resulted in significant microglial responses in terms of morphological reactivity and an increased density of microglial cells from 2 to 20 days after injury. This increased microglial population resulted primarily from microglial proliferation from 1.5 to 3 days, which was supplemented by microglial migration within subdivisions of the nTS between days 2 and 3. Unlike other nerve injuries, CT injury did not result in recruitment of bone marrow-derived precursors. Astrocytes also reacted in the nTS with increased levels of glial fibrillary acidic protein (GFAP) by 3 days, although none showed evidence of cell division. GFAP levels remained increased at 30 days, by which time microglial responses had resolved. These results show that nerve damage to the CT results in central glial responses, which may participate in long-lasting taste alterations following CT lesion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.