ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2012
Matching mice to malignancy: molecular subgroups and models of medulloblastoma.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Modeling pediatric medulloblastoma.Brain pathology (Zurich, Switzerland) · 2020Review
- MEMRI-based imaging pipeline for guiding preclinical studies in mouse models of sporadic medulloblastoma.Magnetic resonance in medicine · 2020Article
- BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation.Cancer cell · 2018Article
- Medulloblastoma in the Molecular Era.Journal of Korean Neurosurgical Society · 2018Review
- Patient-derived Tumor Models for Diffuse Intrinsic Pontine Gliomas.Current neuropharmacology · 2017Review
- Contemporary murine models in preclinical astrocytoma drug development.Neuro-oncology · 2015Review
- In vivo Mn-enhanced MRI for early tumor detection and growth rate analysis in a mouse medulloblastoma model.Neoplasia (New York, N.Y.) · 2014Article
- Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity.Cancer research · 2014Article
- ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma.Experimental hematology & oncology · 2013Article
- Development and characterization of murine models of medulloblastoma extraneural growth in bone.Clinical & experimental metastasis · 2013Article
- Molecular subgroups of medulloblastoma.Expert review of neurotherapeutics · 2012Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionMedulloblastoma, the largest group of embryonal brain tumors, has historically been classified into five variants based on histopathology. More recently, epigenetic and transcriptional analyses of primary tumors have subclassified medulloblastoma into four to six subgroups, most of which are incongruous with histopathological classification. DISCUSSION: Improved stratification is required for prognosis and development of targeted treatment strategies, to maximize cure and minimize adverse effects. Several mouse models of medulloblastoma have contributed both to an improved understanding of progression and to developmental therapeutics. In this review, we summarize the classification of human medulloblastoma subtypes based on histopathology and molecular features. We describe existing genetically engineered mouse models, compare these to human disease, and discuss the utility of mouse models for developmental therapeutics. Just as accurate knowledge of the correct molecular subtype of medulloblastoma is critical to the development of targeted therapy in patients, we propose that accurate modeling of each subtype of medulloblastoma in mice will be necessary for preclinical evaluation and optimization of those targeted therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.