ArticleThe Pediatric infectious disease journal2012
Long-term effects of clearing Helicobacter pylori on growth in school-age children.
Article in The Pediatric infectious disease journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Review
- Article
- Effects ofJournal of clinical medicine · 2022Article
- The future of human malnutrition: rebalancing agency for better nutritional health.Globalization and health · 2021Review
- Helicobacter pylori among symptomatic Egyptian children: prevalence, risk factors, and effect on growth.The Journal of the Egyptian Public Health Association · 2019Article
- Effect of long-term Helicobacter pylori infection on growth of children: a cohort study.World journal of pediatrics : WJP · 2016Article
- Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome.PloS one · 2016Article
- New Diagnostic Strategies for Detection of Helicobacter pylori Infection in Pediatric Patients.Gastroenterology & hepatology · 2014Article
- Metabolic consequences of Helicobacter pylori infection and eradication.World journal of gastroenterology · 2014Review
- Helicobacter pylori infection and extragastric disorders in children: a critical update.World journal of gastroenterology · 2014Review
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundA new Helicobacter pylori infection affects growth velocity negatively, and clearing the infection produces a small significant rebound, but it is not known whether height and weight in children are impacted over the long term.
methodsWe investigated 295 school-age children followed in 2 cohorts, treated (150) and untreated (145), from 2004 for 3.7 years with 1105 child-years of observation. Follow-up intervals were 3 months for anthropometry measurements and 6 months for H. pylori status ascertained by urea breath test. Height in centimeters and weight in kilograms were analyzed using growth models.
resultsA multivariate mixed model that adjusted for age, sex, father's education, and number of siblings found no significant differences in height or weight at baseline by H. pylori status. The same model showed a significant impact of clearing H. pylori across time, with increasing significant differences in average height and weight as the follow-up progressed.
conclusionsChildren who were always negative or who cleared the infection grew significantly faster than those who stayed positive after adjusting for other covariates. This study suggests that school-age children's growth benefits from being treated for H. pylori infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.