ArticleMolecular biology reports2012
Characterization and expression analysis of a trypsin-like serine protease from planarian Dugesia japonica.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Evolutionarily conserved peptidoglycan recognition proteins mediate antibacterial immunity in planarians.iScience · 2026Article
- The ctenophore Mnemiopsis leidyi deploys a rapid injury response dating back to the last common animal ancestor.Communications biology · 2024Article
- The transcriptomic response ofFrontiers in cellular and infection microbiology · 2023Article
- Planarian finds time(less) to fight infection.Virulence · 2017Article
- Regeneration in bipinnaria larvae of the bat star Patiria miniata induces rapid and broad new gene expression.Mechanisms of development · 2016Article
- Protein expression profiling in head fragments during planarian regeneration after amputation.Development genes and evolution · 2015Article
- Characterization and expression analysis of chymotrypsin after bacterial challenge in the mud crab, Scylla paramamosain.Genetics and molecular biology · 2014Article
- Unconventional animal models: a booster for new advances in host-pathogen interactions.Frontiers in cellular and infection microbiology · 2014Review
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Authors and funding
6 authors.
Funding
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Abstract
Trypsin-like serine proteases are involved in large number of processes, especially in digestive degradation and immune responses. Here, we identify the characterization of a trypsin-like serine protease in planarian, Djtry, which interestingly has the incompletely conserved catalytic triad (K, D, and S). Phylogenetic analysis suggests that Djtry is an ancient type of trypsin-like serine proteases. The spatial and temporal expression patterns of Djtry are shown during regenerating and embryonic development by whole-mount in situ hybridization. Djtry is found to display a tissue specific expression pattern, with a predominant expression detected in whole gut region of intact and regenerating planarian. While the tissue- and stage-specific expression patterns during the embryonic development imply the roles of Djtry involve in yolk degradation and gut formation. Quantitative real-time PCR was carried out to analyze the function of this protease in vivo after planarians were stimulated to a bacterial challenge and food. The results showed that Djtry increased after a bacterial challenge and was basically stable for food. Therefore, the trypsin-like serine protease might be involved in the innate defense reactions against bacterial infection.
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