Evidence map›Paper›PMID 22314809›Full record

ReviewCurrent gastroenterology reports2012

Genetics of pancreatitis: an update for clinicians and genetic counselors.

Sheila Solomon, David C Whitcomb

Abstract readReview
In one paragraph

Review in Current gastroenterology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Hereditary pancreatitis: An updated review in pediatrics.World journal of clinical pediatrics · 2022
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. The Surgeon's Role in Treating Chronic Pancreatitis and Incidentally Discovered Pancreatic Lesions.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017
    Review
  12. Review
  13. Article
  14. Hereditary pancreatitis: current perspectives.Clinical and experimental gastroenterology · 2016
    Review
  15. Early detection of pancreatic cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2015
    Review
  16. Article
  17. Article
  18. Genetics and treatment options for recurrent acute and chronic pancreatitis.Current treatment options in gastroenterology · 2014
    Article
  19. Genetics of acute and chronic pancreatitis.Current opinion in gastroenterology · 2013
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sheila SolomonDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
David C Whitcomb

Funding

Feeding and Pancreatic Rest in Acute PancreatitisU01DK075803 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITCOMB, DAVID CLEMENT · 2007 to 2012
$5.4M
North American Pancreatitis Study 2 (NAPS2)R01DK061451 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITCOMB, DAVID CLEMENT · 2002 to 2010
$4.9M
MOLECULAR GENETICS OF HEREDITARY PANCREATITISR01DK054709 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITCOMB, DAVID CLEMENT · 1999 to 2008
$2.0M
NAPS2 Continuation Genome Wide Association Study of PancreatitisR56DK061451 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITCOMB, DAVID CLEMENT · 2011 to 2011
$1.3M
NIDDK NIH HHS DK054709NIDDK NIH HHS DK061451NIDDK NIH HHS DK075803NIDDK NIH HHS R01 DK054709NIDDK NIH HHS R01 DK061451NIDDK NIH HHS R56 DK061451NIDDK NIH HHS U01 DK075803
6 · The paper itself

Abstract

With novel genetic technologies available, there is a paradigm shift in the way that risk assessments, diagnoses,and therapies for genetic susceptibility syndromes are addressed. Hereditary pancreatitis is among these conditions, for which genetic counseling and next generation sequencing, help families better understand, cope with and live healthier lives. Identifying a genetic etiology to a condition formally believed to be solely environmentally induced can alter the path for treatment for many patients. This finding introduces the concept of gene-environment interactions in human disease and the relationship between genetic predisposition and exposure risk in disease development. The genetic counseling process is complex with medical explanations, psychosocial issues relating to coping with diagnosis, potential future health problems, recurrence risks and family planning. These sometimes difficult conversations can be facilitated by a genetic counselor as a member of the multidisciplinary team. This chapter addresses the intricate medical and psychosocial issues that can arise in the setting of treating patients with hereditary pancreatitis.

Indexed as

Genetic CounselingGenetic Predisposition to DiseaseGenetic TestingGenotypeHumansPancreatitisRisk Assessment

Identifiers

PMID22314809
PMCPMC5654383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.