ReviewParasitology research2012
The immune response to parasitic helminths of veterinary importance and its potential manipulation for future vaccine control strategies.
Review in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Th1 and Th2 cytokine gene expression in primary infection and vaccination against Fasciola gigantica in buffaloes by real-time PCR.Parasitology research · 2013Trial
- Associations between subclinical bovine respiratory disease, growth patterns, and the nasal and fecal microbiota in dairy replacement heifers: a retrospective study.Frontiers in veterinary science · 2026Article
- Concomitant immunity in persistent Leishmania infections: could it represent an evolutionary balance and a vaccine target?Parasites & vectors · 2025Review
- The use of systemic immune inflammatory index as a predictor for nematodes infections in horses.Parasite epidemiology and control · 2025Article
- Article
- Helminth co-infections have no additive detrimental impact on milk yield and milk quality compared to mono-infections in German dairy cows.Parasites & vectors · 2024Article
- Th2-biased immune responses to body migrating Ascaris larvae in primary infection are associated with pathology but not protection.Scientific reports · 2024Article
- A survey of gastrointestinal helminth infestation in smallholder backyard pigs and the first molecular identification of the two zoonotic helminths Ascaris suum and Trichuris suis in Myanmar.BMC veterinary research · 2024Article
- Influence of seasonality and biological activity on infection by helminths in Cantabrian bear.International journal for parasitology. Parasites and wildlife · 2024Article
- Occurrence and Risk Factors Associated withAnimals : an open access journal from MDPI · 2024Article
- Age-dependent relationships among diet, body condition, and Echinococcus multilocularis infection in urban coyotes.PloS one · 2023Article
- Article
- Immunization Trials with Recombinant Major Sperm Protein of the Bovine LungwormPathogens (Basel, Switzerland) · 2022Article
- Endoparasitism of Golden Retrievers: Prevalence, risk factors, and associated clinicopathologic changes.PloS one · 2022Article
- Article
- Allele substitution and dominance effects of CD166/ALCAM gene polymorphisms for endoparasite resistance and test-day traits in a small cattle population using logistic regression analyses.Mammalian genome : official journal of the International Mammalian Genome Society · 2019Article
- Genome-wide associations and functional gene analyses for endoparasite resistance in an endangered population of native German Black Pied cattle.BMC genomics · 2019Article
- Th1/Th2 balance and humoral immune response to potential antigens as early diagnostic method of equineVeterinary world · 2017Article
- Nanocarriers for spleen targeting: anatomo-physiological considerations, formulation strategies and therapeutic potential.Drug delivery and translational research · 2016Review
- Alaria mesocercariae in the tails of red-sided garter snakes: evidence for parasite-mediated caudectomy.Parasitology research · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the increasing knowledge of the immunobiology and epidemiology of parasitic helminths of the gastrointestinal system and the cardiorespiratory system, complications arising from infections of animals and humans with these parasites are a major clinical and economic problem. This has been attributed to the high incidence of these parasites, the widespread emergence of multi-drug resistant parasite strains and the lack of effective vaccines. Efforts to develop and produce vaccines against virtually all helminths (with the exception of Dictyocaulus viviparus and some cestode species) have been hindered by the complexity of the host-parasite relationship, and incomplete understanding of the molecular and immune regulatory pathways associated with the development of protective immunity against helminths. Novel genomic and proteomic technologies have provided opportunities for the discovery and characterisation of effector mechanisms and molecules that govern the host-parasite interactions in these two body systems. Such knowledge provided clues on how appropriate and protective responses are elicited against helminths and, thus, may lead to the development of effective therapeutic strategies. Here, we review advances in the immune response to selected helminths of animal health significance, and subsequent vaccine potential. The topics addressed are important for understanding how helminths interact with host immune defences and also are relevant for understanding the pathogenesis of diseases caused by helminths.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.