ArticleIntegrative biology : quantitative biosciences from nano to macro2012
Epithelial cell guidance by self-generated EGF gradients.
Article in Integrative biology : quantitative biosciences from nano to macro, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed.
- Nongenetic adaptation by collective migration.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- pH-regulated single cell migration.Pflugers Archiv : European journal of physiology · 2024Review
- Microfluidic devices for precise measurements of cell directionality reveal a role for glutamine during cell migration.Scientific reports · 2023Article
- Tumour follower cells: A novel driver of leader cells in collective invasion (Review).International journal of oncology · 2023Review
- Deformability and collision-induced reorientation enhance cell topotaxis in dense microenvironments.Biophysical journal · 2023Article
- A self-generated Toddler gradient guides mesodermal cell migration.Science advances · 2022Article
- Collective behavior and nongenetic inheritance allow bacterial populations to adapt to changing environments.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dynamics of diffusive cell signaling relays.eLife · 2020Article
- Analysis of barotactic and chemotactic guidance cues on directional decision-making ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Primary and Metastatic Pancreatic Cancer Cells Exhibit Differential Migratory Potentials.Pancreas · 2020Article
- The Computational Boundary of a "Self": Developmental Bioelectricity Drives Multicellularity and Scale-Free Cognition.Frontiers in psychology · 2019Article
- Cell Sequence and Mitosis Affect Fibroblast Directional Decision-Making During Chemotaxis in Microfluidic Mazes.Cellular and molecular bioengineering · 2018Article
- A compact low-cost low-maintenance open architecture mask aligner for fabrication of multilayer microfluidics devices.Biomicrofluidics · 2018Article
- Multicompartment cell-based modeling of confined migration: regulation by cell intrinsic and extrinsic factors.Molecular biology of the cell · 2018Article
- Cell-Cell Contact and Receptor Tyrosine Kinase Signaling.Cold Spring Harbor perspectives in biology · 2018Review
- Determining whether observed eukaryotic cell migration indicates chemotactic responsiveness or random chemokinetic motion.Journal of theoretical biology · 2017Article
- Moving in and Out: Dispersion of Cells in Self-Generated Gradients.Journal of clinical & cellular immunology · 2017Article
- Chemotactic network responses to live bacteria show independence of phagocytosis from chemoreceptor sensing.eLife · 2017Article
- The Arp2/3 inhibitory protein Arpin is dispensable for chemotaxis.Biology of the cell · 2017Review
- Cancer cell motility: lessons from migration in confined spaces.Nature reviews. Cancer · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Cancer epithelial cells often migrate away from the primary tumor to invade into the surrounding tissues. Their migration is commonly assumed to be directed by pre-existent spatial gradients of chemokines and growth factors in the target tissues. Unexpectedly however, we found that the guided migration of epithelial cells is possible in vitro in the absence of pre-existent chemical gradients. We observed that both normal and cancer epithelial cells can migrate persistently and reach the exit along the shortest path from microscopic mazes filled with uniform concentrations of media. Using microscale engineering techniques and biophysical models, we uncovered a self-guidance strategy during which epithelial cells generate their own guiding cues under conditions of biochemical confinement. The self-guidance strategy depends on the balance between three interdependent processes: epidermal growth factor (EGF) uptake by the cells (U), the restricted transport of EGF through the structured microenvironment (T), and cell chemotaxis toward the resultant EGF gradients (C). The UTC self-guidance strategy can be perturbed by inhibition of signalling through EGF-receptors and appears to be independent from chemokine signalling. Better understanding of the UTC self-guidance strategy could eventually help devise new ways for modulating epithelial cell migration and delaying cancer cell invasion or accelerating wound healing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.