ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2012
Radiation-induced cranial neuropathy in patients with nasopharyngeal carcinoma. A follow-up study.
Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Efficacy and safety of acupuncture for dysphagia after radiotherapy or chemoradiotherapy in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Active raster scanning with carbon ions: reirradiation in patients with recurrent skull base chordomas and chondrosarcomas.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014Trial
- Prevalence of function-limiting late effects in survivors of head and neck cancer.PM & R : the journal of injury, function, and rehabilitation · 2025Article
- The Current Position of Postoperative Radiotherapy for Salivary Gland Cancer: A Systematic Review and Meta-Analysis.Cancers · 2024Review
- Review
- Longitudinal functional outcomes and late effects of radiation following treatment of nasopharyngeal carcinoma: secondary analysis of a prospective cohort study.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2022Observational
- State of Rehabilitation Research in the Head and Neck Cancer Population: Functional Impact vs. Impairment-Focused Outcomes.Current oncology reports · 2022Review
- Review
- Bevacizumab Combined with Corticosteroids Does Not Improve the Clinical Outcome of Nasopharyngeal Carcinoma Patients With Radiation-Induced Brain Necrosis.Frontiers in oncology · 2021Article
- Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities.Ecancermedicalscience · 2020Review
- Quality of Life, Toxicity and Unmet Needs in Nasopharyngeal Cancer Survivors.Frontiers in oncology · 2020Review
- Incidence and outcomes of radiation-induced late cranial neuropathy in 10-year survivors of head and neck cancer.Oral oncology · 2019Article
- Delayed lower cranial neuropathy after oropharyngeal intensity-modulated radiotherapy: A cohort analysis and literature review.Head & neck · 2017Review
- Review
- Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study.Oncotarget · 2016Article
- Radiation-induced lower cranial nerve palsy in patients with head and neck carcinoma.Molecular and clinical oncology · 2015Article
- New Onset Diplopia in Patients with Nasopharyngeal Carcinoma following Concurrent Chemoradiotherapy: Clinical Features and Etiology.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
goalThe purpose of the current study was to investigate the long-term characteristics of radiation-induced cranial nerve injury in nasopharyngeal carcinoma (NPC) patients. PATIENTS AND
methodsWe studied cranial nerve palsy (CNP) in 328 NPC patients who received radiotherapy between 1994 and 2006. Follow-up was 93.6% complete as of December 2009. A total of 72 patients with CNP were recruited for analysis (56 men and 16 women). Patients with evidence of residual or recurrent tumor accompanied by CNP were excluded. The characteristics of CNP and the relationship with the radiation fields as well as re-ratiotherapy were evaluated.
resultsAfter a mean follow-up of 11.2 years, 72 patients were found to have developed CNP. The latency of palsy ranged from 0.6–16.0 years. For the 67 patients with first course radiation, the glossopharyngeal and vagus nerves were the most vulnerable combination, occurring in 57 patients (85.1%). Patients with facial–cervical field radiation had a significantly longer latency comparing with that of patients with facial–cervical split fields (p = 0.021). In the first 5 years, 49.3% of patients developed CNP, while 40.3% presented CNP in the second 5-year period. In patients with first course radiation, 61 patients had more than one CNP. With regard to the 5 patients with re-radiation, most of them had multiple upper cranial nerve injuries.
conclusionRadiation therapy of NPC patients may lead to cranial neuropathy. Patients with facial–cervical radiation fields had a longer latency for the manifestation of CNP compared with those patients who were treated with split fields. In patients with re-radiotherapy, the frequency of upper cranial nerve injury increased greatly.
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