Evidence map›Paper›PMID 22314496›Full record

ArticleThe Prostate2012

A joint effect of new Western diet and retinoid X receptor α prostate-specific knockout with development of high-grade prostatic intraepithelial neoplasia in mice--a preliminary study.

Gloria E Mao, Diane M Harris, Aune Moro, David Heber, Pradip Roy-Burman, Zuo-Feng Zhang, Jianyu Rao

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Prostate, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gloria E MaoCenter for Human Nutrition, UCLA School of Public Health, UCLA, Los Angeles, CA, USA.
Diane M Harris
Aune Moro
David Heber
Pradip Roy-Burman
Zuo-Feng Zhang
Jianyu Rao
UCLA Health · USUniversity of Southern California · US

Funding

PATHOGENESIS OF HUMAN PROSTATE CARCINOMASR01CA059705 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROY-BURMAN, PRADIP · 1993 to 2012
$7.3M
UCLA Career Development Program in Cancer Prevention and Control ResearchR25CA087949 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BASTANI, ROSHAN · 2000 to 2014
$6.8M
UCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3M
The UCLA Clinical Nutrition Research UnitP30CA042710 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HEBER, DAVID · 2002 to 2006
$4.0M
Prostate Cancer Molecular Epidemiology-Retinoid ReceptorK07CA098880 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAO, GLORIA E · 2003 to 2004
$254k
NCI NIH HHS 5-R25-CA87949NCI NIH HHS CA T32 CA09142NCI NIH HHS K07 CA098880NCI NIH HHS K07 CA98880NCI NIH HHS P30 CA042710NCI NIH HHS P30 CA 42710NCI NIH HHS R01 CA059705NCI NIH HHS R01 CA59705NCI NIH HHS R25 CA087949NCI NIH HHS T32 CA009142
6 · The paper itself

Abstract

backgroundThe "New Western-style Diet" (NWD) characterized by high in fat and low in fiber, vitamin D, calcium, and methyl donors--are considered as a risk factor for prostate cancer. Previous studies have shown that premalignant lesions of human prostate have decreased expression of the Retinoid X Receptor alpha (RXRα). This study was to determine the effect of diet in RXRα knockout mice in developing high-grade prostate intraepithelial neoplasia (mPIN).

methodsMale mice (n = 54) with or without the RXRα prostate null mutation were fed either NWD or AIN-76A control diet for 10 months; prostates were harvested at 11 months of age and examined for prostate mPIN.

resultsmPIN was seen in 79% of RXRα prostate null mice fed NWD (n = 19), 30.8% RXRα prostate null mice fed AIN-76A (n = 13), 42.9% RXRα wild-type mice fed NWD (n = 14), and 12.5% RXRα wild-type mice fed AIN-76A (n = 8). Unconditional Logistic analysis showed a significant joint effect of NWD and RXRα status in developing mPIN 26.3 (95% CI: 2.5-280), but interaction was not significant owing to the small sample size 1.6 (0.09-27.7, P = 0.7441).

conclusionThis study provides preliminary data to support a joint RXRα-diet effect in prostate carcinogenesis.

Indexed as

AnimalsDiet, High-FatMaleMiceMice, KnockoutProstatic Intraepithelial NeoplasiaProstatic NeoplasmsRandom AllocationRetinoid X Receptor alphaRetinoid X Receptor alpha

Identifiers

PMID22314496
PMCPMC4321893
OpenAlexW2006389478

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.