ArticleEuropean journal of nutrition2013
Neuroprotective effects of digested polyphenols from wild blackberry species.
Article in European journal of nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 84 citations in OpenAlex.
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- A Review on Chromatography-Mass Spectrometry Applications on Anthocyanin and Ellagitannin Metabolites of Blackberries and Raspberries.Foods (Basel, Switzerland) · 2021Review
- A Red-Berry Mixture as a Nutraceutical: Detailed Composition and Neuronal Protective Effect.Molecules (Basel, Switzerland) · 2021Article
- Insight in the Recent Application of Polyphenols From Biomass.Frontiers in bioengineering and biotechnology · 2021Review
- Fruit Quality Characterization of New Sweet Cherry Cultivars as a Good Source of Bioactive Phenolic Compounds with Antioxidant and Neuroprotective Potential.Antioxidants (Basel, Switzerland) · 2020Article
- RNA-seq, de novo transcriptome assembly and flavonoid gene analysis in 13 wild and cultivated berry fruit species with high content of phenolics.BMC genomics · 2019Article
- Blood-brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study.European journal of nutrition · 2019Article
- Nutrients in the Prevention of Alzheimer's Disease.Oxidative medicine and cellular longevity · 2019Review
- (Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis.Scientific reports · 2018Article
- Extracts ofFrontiers in chemistry · 2018Article
- Biochemical Properties and Neuroprotective Effects of Compounds in Various Species of Berries.Molecules (Basel, Switzerland) · 2017Review
- Polyphenols journey through blood-brain barrier towards neuronal protection.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBlackberry ingestion has been demonstrated to attenuate brain degenerative processes with the benefits ascribed to the (poly)phenolic components. The aim of this work was to evaluate the neuroprotective potential of two wild blackberry species in a neurodegeneration cell model and compare them with a commercial variety.
methodsThis work encompasses chemical characterization before and after an in vitro digestion and the assessment of neuroprotection by digested metabolites. Some studies targeting redox/cell death systems were also performed to assess possible neuroprotective molecular mechanisms.
resultsThe three blackberry extracts presented some quantitative differences in polyphenol composition that could be responsible for the different responses in the neurodegeneration cell model. Commercial blackberry extracts were ineffective but both wild blackberries, Rubus brigantinus and Rubus vagabundus, presented neuroprotective effects. It was verified that a diminishment of intracellular ROS levels, modulation of glutathione levels and activation of caspases occurred during treatment. The last effect suggests a preconditioning effect since caspase activation was not accompanied by diminution in cell death and loss of functionality.
conclusionsThis is the first time that metabolites obtained from an in vitro digested food matrix, and tested at levels approaching the concentrations found in human plasma, have been described as inducing an adaptative response.
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