ArticleMalaria journal2012
Human cerebral malaria and Plasmodium falciparum genotypes in Malawi.
Article in Malaria journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- KASP: a genotyping method to rapid identification of resistance in Plasmodium falciparum.Malaria journal · 2021Article
- Article
- Intra-host dynamics of co-infecting parasite genotypes in asymptomatic malaria patients.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Article
- Distinct parasite populations infect individuals identified through passive and active case detection in a region of declining malaria transmission in southern Zambia.Malaria journal · 2017Article
- Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research.The American journal of tropical medicine and hygiene · 2015Article
- Subtle changes in Plasmodium falciparum infection complexity following enhanced intervention in Malawi.Acta tropica · 2015Article
- Differential PfEMP1 expression is associated with cerebral malaria pathology.PLoS pathogens · 2014Article
- Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi.Scientific reports · 2014Article
- Plasmodium falciparum gene expression measured directly from tissue during human infection.Genome medicine · 2014Article
- Two new rapid SNP-typing methods for classifying Mycobacterium tuberculosis complex into the main phylogenetic lineages.PloS one · 2012Article
Corrections and comments
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Authors and funding
22 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundCerebral malaria, a severe form of Plasmodium falciparum infection, is an important cause of mortality in sub-Saharan African children. A Taqman 24 Single Nucleotide Polymorphisms (SNP) molecular barcode assay was developed for use in laboratory parasites which estimates genotype number and identifies the predominant genotype.
methodsThe 24 SNP assay was used to determine predominant genotypes in blood and tissues from autopsy and clinical patients with cerebral malaria.
resultsSingle genotypes were shared between the peripheral blood, the brain, and other tissues of cerebral malaria patients, while malaria-infected patients who died of non-malarial causes had mixed genetic signatures in tissues examined. Children with retinopathy-positive cerebral malaria had significantly less complex infections than those without retinopathy (OR = 3.7, 95% CI [1.51-9.10]).The complexity of infections significantly decreased over the malaria season in retinopathy-positive patients compared to retinopathy-negative patients.
conclusionsCerebral malaria patients harbour a single or small set of predominant parasites; patients with incidental parasitaemia sustain infections involving diverse genotypes. Limited diversity in the peripheral blood of cerebral malaria patients and correlation with tissues supports peripheral blood samples as appropriate for genome-wide association studies of parasite determinants of pathogenicity.
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