ArticleThe Journal of physiology1990
An ATP-activated conductance in pheochromocytoma cells and its suppression by extracellular calcium.
Article in The Journal of physiology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 129 citations in OpenAlex.
- ATP mediates a negative autocrine signal on stimulus-secretion coupling in mouse pancreatic β-cells.Endocrine · 2019Article
- Optical control of trimeric P2X receptors and acid-sensing ion channels.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Differences in purinergic amplification of osmotic cell lysis by the pore-forming RTX toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: the role of pore size.Infection and immunity · 2013Article
- Purinergic signalling and cancer.Purinergic signalling · 2013Review
- Octyl Gallate Inhibits ATP-induced Intracellular Calcium Increase in PC12 Cells by Inhibiting Multiple Pathways.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2010Article
- Excitatory effect of ATP on rat area postrema neurons.Purinergic signalling · 2006Article
- Biophysics of P2X receptors.Pflugers Archiv : European journal of physiology · 2006Review
- Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic ganglia.The Journal of physiology · 2001Article
- Rat chromaffin cells lack P2X receptors while those of the guinea-pig express a P2X receptor with novel pharmacology.British journal of pharmacology · 1999Article
- Single channel properties of P2X2 purinoceptors.The Journal of general physiology · 1999Article
- ATP P2X receptors mediate fast synaptic transmission in the dorsal horn of the rat spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- An ATP-gated cation channel with some P2Z-like characteristics in gastric smooth muscle cells of toad.The Journal of physiology · 1997Article
- P2x-purinoceptors of myenteric neurones from the guinea-pig ileum and their unusual pharmacological properties.British journal of pharmacology · 1996Article
- Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells.The Journal of physiology · 1996Article
- Fading and rebound of currents induced by ATP in PC12 cells.British journal of pharmacology · 1996Article
- Functional characterisation of P2 purinoceptors in PC12 cells by measurement of radiolabelled calcium influx.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Characterization of Na+ influx mediated by ATP(4-)-activated P2 purinoceptors in PC12 cells.British journal of pharmacology · 1996Article
- Potassium current inhibition by nonselective cation channel-mediated sodium entry in rat pheochromocytoma (PC-12) cells.Biophysical journal · 1996Article
- Effect of intracellular calcium on ATP-activated, GTP-dependent calcium channels in rat macrophages.The Journal of physiology · 1996Article
- ATP activates non-selective cation channels and calcium release in inner hair cells of the guinea-pig cochlea.The Journal of physiology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. ATP-activated inward current in PC12 pheochromocytoma cells was characterized using the whole-cell voltage-clamp technique. 2. ATP (100 microM) applied extracellular elicited an inward rectifying current with a reversal potential of about +7 mV. The current was desensitized in seconds in spite of continued presence of ATP. 3. A comparison was made of the ability of ATP and its analogues. The order of potency in activating the inward current was ATP greater than ATP gamma S greater than ADP; AMP, adenosine and alpha, beta-methylene ATP were inactive at concentrations up to mM. 4. The ATP-activated current was also observed when external Na+ and Ca2+ were replaced with K+, TEA, Tris or glucosamine. The order of ion selectivity was Na+ greater than K+ greater than TEA not equal to Tris greater than glucosamine. 5. The ATP-activated current was also recorded in extracellular solutions containing Ca2+ as the only external cation. The amplitude increased as the concentration of Ca2+ was increased in the range between 1.8 and 16.2 mM. However, the current amplitude decreased at higher Ca2+ concentrations and the current was not recorded in 110 mM-Ca2+ solution. 6. In the presence of 140 mM-Na+ in the external solution, the current amplitude also decreased as the external Ca2+ concentration was increased (from 1.8 to 16.2 mM). 7. The results indicate that Ca2+ as well as monovalent cations permeate through the ATP-sensitive pathway and that Ca2+ blocks ion permeation, including its own permeation through the pathway. This regulation by extracellular Ca2+ is different to the ATP-activated current in smooth muscle cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.