Evidence map›Paper›PMID 22314084›Full record

Trial reportJournal of feline medicine and surgery2012

Acceptability and compliance of atenolol tablet, compounded paste and compounded suspension prescribed to healthy cats*.

Kuan Hua Khor, Fiona Campbell, Michael J Rathbone, Ristan M Greer, Paul C Mills

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of feline medicine and surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kuan Hua KhorSchool of Veterinary Science, The University of Queensland, Gatton Campus, Queensland, Australia.
Fiona Campbell
Michael J Rathbone
Ristan M Greer
Paul C Mills

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was designed to evaluate the cats' acceptance and compliance of the owners and cats towards an extemporaneously prepared palatable compounded atenolol (paste and suspension) formulation in comparison to the commercially obtained tablet, in a randomised, cross-over study design.The three formulations were prescribed twice daily for 6 days to 13 healthy privately-owned cats of 13 different owners, with varying levels of experience in medicating cats. Daily compliance was evaluated via an owner-completed diary, completed after each dose administered. Owner's experience and preference of the formulation was evaluated via questionnaires given prior to, at the end of each treatment protocol, and upon completion of the study. Although compounded suspension was association with fewest missed doses, the majority of cat owners expressed a preference for the divided tablet. Atenolol tablets, compounded paste and suspension acceptance and compliance were comparable. Further work is now required to assess the amount and stability of the active ingredient and the robustness of the paste and suspension formulations prior to any bioavailability comparisons between the formulations.

Indexed as

Behavior, AnimalAdministration, OralAnimalsAntihypertensive AgentsAtenololCatsCross-Over StudiesDrug CompoundingFemaleMaleOintmentsPharmaceutical SolutionsTabletsAntihypertensive AgentsAtenololOintmentsPharmaceutical SolutionsTablets

Identifiers

PMID22314084
PMCPMC10822486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.