Evidence map›Paper›PMID 22313958›Full record

ArticleAIDS (London, England)2012

Small for gestational age birth outcomes in pregnant women with perinatally acquired HIV.

Jennifer Jao, Keith M Sigel, Katherine T Chen, Gabriela Rodriguez-Caprio, Roberto Posada, Gail Shust, Juan Wisnivesky, Elaine J Abrams, Rhoda S Sperling

Open access · greenAbstract read
In one paragraph

Article in AIDS (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
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  7. The next generation: Pregnancy in adolescents and women living with perinatally acquired HIV in South Africa.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 2021
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  15. Viral Suppression and Resistance in a Cohort of Perinatally-HIV Infected (PHIV+) Pregnant Women.International journal of environmental research and public health · 2016
    Article
  16. Article
  17. Risk of intrauterine growth restriction among HIV-infected pregnant women: a cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015
    Article
  18. Article
  19. Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de Janeiro.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jennifer JaoDivision of Infectious Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. jennifer.jao@mssm.edu
Keith M Sigel
Katherine T Chen
Gabriela Rodriguez-Caprio
Roberto Posada
Gail Shust
Juan Wisnivesky
Elaine J Abrams
Rhoda S Sperling
Icahn School of Medicine at Mount Sinai · USGeneral Department of Preventive Medicine · VNOffice of Infectious Diseases · US

Funding

Metabolic Effects of In Utero Antiretrovirals on HIV Exposed Uninfected InfantsK23HD070760 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JAO, JENNIFER · 2012 to 2016
$647k
NICHD NIH HHS K23 HD070760
6 · The paper itself

Abstract

objectiveTo compare small for gestational age (SGA) birth weight in children born to women with perinatally acquired HIV (PAH) vs. those with behaviorally acquired HIV (BAH).

designRetrospective cohort study of HIV-infected pregnant women who received care and delivered a live born at a single hospital in New York City from January 2004 to April 2011.

methodsWe collected data via chart review on demographics, behavioral risk factors, HIV clinical markers, antiretroviral therapy (ART), mode of HIV acquisition, and pregnancy outcomes on study participants. We compared rates of these exposures among participants by method of HIV acquisition. Generalized Estimating Equation was applied to evaluate the effect of HIV acquisition type on SGA birth weight, adjusting for potential confounders.

resultsOf 87 live births evaluated, 17 were born to 14 women with PAH. Overall, 20 (23%) were SGA. Eight of these SGA neonates were born preterm. Live births to women with PAH were more likely to be born SGA in our unadjusted analysis [odds ratio (OR) = 4.13, 95% confidence interval (CI) = 1.38-12.41). After adjusting for mother's age, substance use during pregnancy, nadir CD4 cell count during pregnancy, viral suppression at delivery, and second-line ART use during pregnancy, this relationship persisted with an adjusted OR of 5.7 (95% CI = 1.03-31.61).

conclusionIn comparison to infants born to women with BAH, infants born to women with PAH were at high risk for compromised intrauterine growth. Future studies are warranted to determine possible causal mechanisms.

Indexed as

Infant, Small for Gestational AgeAdultFemaleHIV InfectionsHumansInfant, NewbornNew York CityPregnancyPregnancy Complications, InfectiousPregnancy OutcomeRetrospective StudiesRisk FactorsRisk-TakingYoung Adult

Identifiers

PMID22313958
PMCPMC3912863
OpenAlexW2016747308

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.