ArticleMicrobiology (Reading, England)2012
Treponema denticola chymotrypsin-like proteinase (CTLP) integrates spirochaetes within oral microbial communities.
Article in Microbiology (Reading, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Metagenomics as an Effective Diagnostic Approach for Exploring Oral Microbial Diversity and Dental Diseases: A Narrative Review.International journal of clinical pediatric dentistry · 2026Review
- Research progress and antibacterial mechanisms of plant essential oils as alternative therapies for periodontitis.Frontiers in microbiology · 2026Review
- In Vivo Regulation of Active Matrix Metalloproteinase-8 (aMMP-8) in Periodontitis: From Transcriptomics to Real-Time Online Diagnostics and Treatment Monitoring.Diagnostics (Basel, Switzerland) · 2024Article
- Parvimonas micra can translocate from the subgingival sulcus of the human oral cavity to colorectal adenocarcinoma.Molecular oncology · 2024Article
- An inflammatory paradox: strategies inflammophilic oral pathobionts employ to exploit innate immunity via neutrophil manipulation.Frontiers in oral health · 2024Article
- Who is in the driver's seat? Parvimonas micra: An understudied pathobiont at the crossroads of dysbiotic disease and cancer.Environmental microbiology reports · 2023Review
- Development of the First Tractable Genetic System for Parvimonas micra, a Ubiquitous Pathobiont in Human Dysbiotic Disease.Microbiology spectrum · 2022Article
- Porphyromonas gingivalis outside the oral cavity.Odontology · 2022Review
- The Oral Bacterial Microbiome of Interdental Surfaces in Adolescents According to Carious Risk.Microorganisms · 2019Article
- Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation.British journal of cancer · 2018Article
- Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?Journal of immunology research · 2018Review
- Insight into Oral Biofilm: Primary, Secondary and Residual Caries and Phyto-Challenged Solutions.The open dentistry journal · 2017Review
- Article
- Linkages between oral commensal bacteria and atherosclerotic plaques in coronary artery disease patients.NPJ biofilms and microbiomes · 2016Article
- Porphyromonas gingivalis and Treponema denticola exhibit metabolic symbioses.PLoS pathogens · 2014Article
- Intercellular communications in multispecies oral microbial communities.Frontiers in microbiology · 2014Review
- Characterization of Treponema denticola mutants defective in the major antigenic proteins, Msp and TmpC.PloS one · 2014Article
- Intracellular localization of Treponema denticola chymotrypsin-like proteinase in chronic periodontitis.Journal of oral microbiology · 2014Article
- Comparative analysis of oral treponemes associated with periodontal health and disease.BMC infectious diseases · 2013Article
- Microbial interactions in building of communities.Molecular oral microbiology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Treponema denticola is found ubiquitously in the human oral cavity and is mainly associated with bacterial communities implicated in the establishment and development of periodontal disease. The ability to become integrated within biofilm communities is crucial to the growth and survival of oral bacteria, and involves inter-bacterial coaggregation, metabolic cooperation, and synergy against host defences. In this article we show that the chymotrypsin-like proteinase (CTLP), found within a high-molecular-mass complex on the cell surface, mediates adherence of T. denticola to other potential periodontal pathogens, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia and Parvimonas micra. Proteolytic activity per se did not appear to be required for the interactions, and expression of the major outer-sheath protein (Msp) was not necessary, except for binding Parv. micra. Biofilms of densely packed cells and matrix, up to 40 µm in depth, were formed between T. denticola and P. gingivalis on salivary pellicle, with T. denticola cells enriched in the upper layers. Expression of CTLP, but not Msp, was critical for dual-species biofilm formation with P. gingivalis. T. denticola did not form dual-species biofilms with any of the other three periodontal bacterial species under various conditions. Synergy between T. denticola and P. gingivalis was also shown by increased inhibition of blood clotting, which was CTLP-dependent. The results demonstrate the critical role of CTLP in interactions of T. denticola with other oral micro-organisms, leading to synergy in microbial community development and host tissue pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.