ArticlePhysical biology2012
Invasion from a cell aggregate--the roles of active cell motion and mechanical equilibrium.
Article in Physical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- A Simple Framework for Agent-Based Modeling with Extracellular Matrix.Bulletin of mathematical biology · 2025Article
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- A mesoscale mechanical model of cellular interactions.Biophysical journal · 2021Article
- Enhanced persistence and collective migration in cooperatively aligning cell clusters.Biophysical journal · 2021Article
- Collective invasion of glioma cells through OCT1 signalling and interaction with reactive astrocytes after surgery.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Multiscale modelling of motility wave propagation in cell migration.Scientific reports · 2020Article
- Soluble VEGFR1 signaling guides vascular patterns into dense branching morphologies.Journal of theoretical biology · 2018Article
- Multicompartment cell-based modeling of confined migration: regulation by cell intrinsic and extrinsic factors.Molecular biology of the cell · 2018Article
- MMP Secretion Rate and Inter-invadopodia Spacing Collectively Govern Cancer Invasiveness.Biophysical journal · 2018Article
- Role of extracellular matrix and microenvironment in regulation of tumor growth and LAR-mediated invasion in glioblastoma.PloS one · 2018Article
- The biology and mathematical modelling of glioma invasion: a review.Journal of the Royal Society, Interface · 2017Review
- Tumour heterogeneity promotes collective invasion and cancer metastatic dissemination.Royal Society open science · 2017Article
- Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Physical models of collective cell motility: from cell to tissue.Journal of physics D: Applied physics · 2017Article
- Modeling cell shape and dynamics on micropatterns.Cell adhesion & migration · 2016Article
- Collective Signal Processing in Cluster Chemotaxis: Roles of Adaptation, Amplification, and Co-attraction in Collective Guidance.PLoS computational biology · 2016Article
- In vivo confinement promotes collective migration of neural crest cells.The Journal of cell biology · 2016Article
- Ring-Shaped Microlanes and Chemical Barriers as a Platform for Probing Single-Cell Migration.Scientific reports · 2016Article
- The Molecular Basis of Radial Intercalation during Tissue Spreading in Early Development.Developmental cell · 2016Article
- Dynamics of Cell Ensembles on Adhesive Micropatterns: Bridging the Gap between Single Cell Spreading and Collective Cell Migration.PLoS computational biology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Cell invasion from an aggregate into a surrounding extracellular matrix (ECM) is an important process during development disease, e.g., vascular network assembly or tumor progression. To describe the behavior emerging from autonomous cell motility, cell-cell adhesion and contact guidance by ECM filaments, we propose a suitably modified cellular Potts model. We consider an active cell motility process in which internal polarity is governed by a positive feedback from cell displacements, a mechanism that can result in highly persistent motion when constrained by an oriented ECM structure. The model allows us to explore the interplay between haptotaxis, matrix degradation and active cell movement. We show that for certain conditions the cells are able to both invade the ECM and follow the ECM tracks. Furthermore, we argue that enforcing mechanical equilibrium within a bulk cell mass is of key importance in multicellular simulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.