ArticleInternational archives of medicine2012
Autologous stromal vascular fraction therapy for rheumatoid arthritis: rationale and clinical safety.
Article in International archives of medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 44 citations in OpenAlex.
- Investigation of the stemness and wound-healing potential of long-term cryopreserved stromal vascular fraction cells.Regenerative therapy · 2025Article
- A Novel Benchtop Device for Efficient and Simple Purification of Cytokines, Growth Factors and Stem Cells from Adipose Tissue.Biomedicines · 2023Article
- Osteocalcin biomarker level evaluation on fracture healing with bone defect after stromal vascular fraction application in murine model.Annals of medicine and surgery (2012) · 2021Article
- Mesenchymal stem/stromal cell-based therapy for the treatment of rheumatoid arthritis: An update on preclinical studies.EBioMedicine · 2021Review
- Safety of Technique and Procedure of Stromal Vascular Fraction Therapy: From Liposuction to Cell Administration.Scientifica · 2020Article
- Cryopreservation of Stromal Vascular Fraction Cells Reduces Their Counts but Not Their Stem Cell Potency.Plastic and reconstructive surgery. Global open · 2019Article
- A short-term plastic adherence incubation of the stromal vascular fraction leads to a predictable GMP-compliant cell-product.BioImpacts : BI · 2019Article
- Efficacy and Safety of Autologous Stromal Vascular Fraction in the Treatment of Empty Nose Syndrome.Clinical and experimental otorhinolaryngology · 2018Article
- Regenerative Potential and Inflammation-Induced Secretion Profile of Human Adipose-Derived Stromal Vascular Cells Are Influenced by Donor Variability and Prior Breast Cancer Diagnosis.Stem cell reviews and reports · 2018Article
- Effects of donor age on human adipose-derived adherent stromal cells under oxidative stress conditions.The Journal of international medical research · 2018Article
- Stromal Vascular Fraction Combined with Shock Wave for the Treatment of Peyronie's Disease.Plastic and reconstructive surgery. Global open · 2016Article
- Cell therapy in joint disorders.Sports health · 2015Article
- Migraine and tension-type headache treated with stromal vascular fraction: a case series.Journal of medical case reports · 2014Article
- Exogenous endothelial cells as accelerators of hematopoietic reconstitution.Journal of translational medicine · 2012Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advancements in rheumatoid arthritis (RA) treatment protocols and introduction of targeted biological therapies have markedly improved patient outcomes, despite this, up to 50% of patients still fail to achieve a significant clinical response. In veterinary medicine, stem cell therapy in the form of autologous stromal vascular fraction (SVF) is an accepted therapeutic modality for degenerative conditions with 80% improvement and no serious treatment associated adverse events reported. Clinical translation of SVF therapy relies on confirmation of veterinary findings in targeted patient populations. Here we describe the rationale and preclinical data supporting the use of autologous SVF in treatment of RA, as well as provide 1, 3, 6, and 13 month safety outcomes in 13 RA patients treated with this approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.