Trial reportPain medicine (Malden, Mass.)2012
Addressing both depression and pain in late life: the methodology of the ADAPT study.
Trial report in Pain medicine (Malden, Mass.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Statistical design and analysis in trials of proportionate interventions: a systematic review.Trials · 2019Pooled it
- Effectiveness of Models Used to Deliver Multimodal Care for Chronic Musculoskeletal Pain: a Rapid Evidence Review.Journal of general internal medicine · 2018Pooled it
- Opioid Exposure Negatively Affects Antidepressant Response to Venlafaxine in Older Adults with Chronic Low Back Pain and Depression.Pain medicine (Malden, Mass.) · 2020Trial
- Trajectories in Cerebral Blood Flow Following Antidepressant Treatment in Late-Life Depression: Support for the Vascular Depression Hypothesis.The Journal of clinical psychiatry · 2018Trial
- Operating characteristics of PROMIS four-item depression and anxiety scales in primary care patients with chronic pain.Pain medicine (Malden, Mass.) · 2014Trial
- Treating concurrent chronic low back pain and depression with low-dose venlafaxine: an initial identification of "easy-to-use" clinical predictors of early response.Pain medicine (Malden, Mass.) · 2014Trial
- Chronic Pain and Opioids in the Elderly: Treating the Brain, Not Just the Body.International journal of environmental research and public health · 2026Review
- Integrating psychiatry and family medicine in the management of somatic symptom disorders: Diagnosis, collaboration, and communication strategies.Journal of general and family medicine · 2025Review
- Accelerated brain aging in chronic low back pain.Brain research · 2021Article
- Advancing the screening of fibromyalgia in late-life depression: practical implications for psychiatric settings.International psychogeriatrics · 2015Article
- Review
- Problem-Solving Therapy in the Elderly.Current treatment options in psychiatry · 2014Article
- Negative affect and sleep disturbance may be associated with response to epidural steroid injections for spine-related pain.Archives of physical medicine and rehabilitation · 2014Article
- Risk factors for restricting back pain in older persons.Journal of the American Medical Directors Association · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo describe the methodology of the first NIH-funded clinical trial for seniors with comorbid depression and chronic low back pain.
methodsRandomized controlled effectiveness trial using stepped care methodology. Participants are ≥60 years old. Phase 1 (6 weeks) is open treatment with venlafaxine xr 150 mg/day and supportive management (SM). Response is 2 weeks of PHQ-9 ≤5 and at least 30% improvement in the average numeric rating scale for pain. Nonresponders progress to phase 2 (14 weeks) in which they are randomized to high-dose venlafaxine xr (up to 300 mg/day) with problem solving therapy for depression and pain (PST-DP) or high-dose venlafaxine xr and continued SM. Primary outcomes are the univariate pain and depression response and both observed and self-reported disability. Survival analytic techniques will be used, and the clinical effect size will be estimated with the number needed to treat. We hypothesize that self-efficacy for pain management will mediate response for subjects randomized to venlafaxine xr and PST-DP.
resultsNot applicable.
conclusionsThe results of this trial will inform the care of these complex patients and further understanding of comorbid pain and depression in late life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.