ArticleJournal of clinical periodontology2012
A.actinomycetemcomitans-induced periodontal disease promotes systemic and local responses in rat periodontium.
Article in Journal of clinical periodontology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- Induction of Experimental Peri-Implantitis with Strains Selected from the Human Oral Microbiome.Biomedicines · 2024Article
- Hyperoside ameliorates periodontitis in rats by promoting osteogenic differentiation of BMSCs via activation of the NF-κB pathway.FEBS open bio · 2020Article
- CD8Inflammation · 2018Article
- A bacterial-biofilm-induced oral osteolytic infection can be successfully treated by immuno-targeting an extracellular nucleoid-associated protein.Molecular oral microbiology · 2017Article
- Sustained, localized salicylic acid delivery enhances diabetic bone regeneration via prolonged mitigation of inflammation.Journal of biomedical materials research. Part A · 2016Article
- Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B.Scientific reports · 2015Article
- Aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the NLRP3 inflammasome in human macrophages, leading to the release of proinflammatory cytokines.Infection and immunity · 2015Article
- Blockade of the PI-3K signalling pathway by the Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces macrophages to synthesize and secrete pro-inflammatory cytokines.Cellular microbiology · 2014Article
- Perturbation of the indigenous rat oral microbiome by ciprofloxacin dosing.Molecular oral microbiology · 2013Article
- Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives.Journal of Indian Society of PeriodontologyReview
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
aimTo characterize the histologic and cellular response to A. actinomycetemcomitans (Aa) infection. MATERIAL &
methodsWistar rats infected with Aa were evaluated for antibody response, oral Aa colonization, loss of attachment, PMN recruitment, TNF-α in the junctional epithelium and connective tissue, osteoclasts and adaptive immune response in local lymph nodes at baseline and 4, 5 or 6 weeks after infection. Some groups were given antibacterial treatment at 4 weeks.
resultsAn antibody response against Aa occurred within 4 weeks of infection, and 78% of inoculated rats had detectable Aa in the oral cavity (p < 0.05). Aa infection significantly increased loss of attachment that was reversed by antibacterial treatment (p < 0.05). TNF-α expression in the junctional epithelium followed the same pattern. Aa stimulated high osteoclast formation and TNF-α expression in the connective tissue (p < 0.05). PMN recruitment significantly increased after Aa infection (p < 0.05). Aa also increased the number of CD8(+) T cells (p < 0.05), but not CD4(+) T cells or regulatory T cells (Tregs) (p > 0.05).
conclusionAa infection stimulated a local response that increased numbers of PMNs and TNF-α expression in the junctional epithelium and loss of attachment. Both TNF-α expression in JE and loss of attachment was reversed by antibiotic treatment. Aa infection also increased TNF-α in the connective tissue, osteoclast numbers and CD8(+) T cells in lymph nodes. The results link Aa infection with important characteristics of periodontal destruction.
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Registered trials
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