ArticleJournal of the American Chemical Society2012
Quantification of transcription factor binding in cell extracts using an electrochemical, structure-switching biosensor.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- A type of magnetically induced self-assembled electrochemical aptamer nanobiosensor for ultrasensitive detection of hypoxia-inducible factor 1α protein.Frontiers in chemistry · 2026Article
- Rationally Designed DNA-Based Scaffolds and Switching Probes for Protein Sensing.Advances in biochemical engineering/biotechnology · 2024Review
- Rapid and Quantitative Detection of Lung Cancer Biomarker ENOX2 Using a Novel Aptamer in an Electrochemical DNA-Based (E-DNA) Biosensor.Biosensors · 2023Article
- Tailoring electrode surface charge to achieve discrimination and quantification of chemically similar small molecules with electrochemical aptamers.Advanced functional materials · 2023Article
- A Folding-Based Electrochemical Aptasensor for the Single-Step Detection of the SARS-CoV-2 Spike Protein.ACS applied materials & interfaces · 2022Article
- An Allosteric Transcription Factor DNA-Binding Electrochemical Biosensor for Progesterone.ACS sensors · 2022Article
- Controlling Dynamic DNA Reactions at the Surface of Single-Walled Carbon Nanotube Electrodes to Design Hybridization Platforms with a Specific Amperometric Readout.Analytical chemistry · 2022Article
- Electrochemical DNA Biosensor That Detects Early Celiac Disease Autoantibodies.Sensors (Basel, Switzerland) · 2021Article
- Switching the activity of Taq polymerase using clamp-like triplex aptamer structure.Nucleic acids research · 2020Article
- Recent development of nucleic acid nanosensors to detect sequence-specific binding interactions: From metal ions, small molecules to proteins and pathogens.Sensors international · 2020Article
- Bioapplications of DNA nanotechnology at the solid-liquid interface.Chemical Society reviews · 2019Review
- Electrochemical Aptamer-Based Sensors for Rapid Point-of-Use Monitoring of the Mycotoxin Ochratoxin A Directly in a Food Stream.Molecules (Basel, Switzerland) · 2018Article
- Maximizing the Signal Gain of Electrochemical-DNA Sensors.Analytical chemistry · 2016Article
- A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α.Scientific reports · 2016Article
- A Modular, DNA-Based Beacon for Single-Step Fluorescence Detection of Antibodies and Other Proteins.Angewandte Chemie (International ed. in English) · 2015Article
- Nanostructured gold dsDNA sensor for early detection of breast cancer by beta protein 1 (BPJournal of electroanalytical chemistry (Lausanne, Switzerland) · 2015Article
- Folding-upon-binding and signal-on electrochemical DNA sensor with high affinity and specificity.Analytical chemistry · 2014Article
- Detecting transforming growth factor-β release from liver cells using an aptasensor integrated with microfluidics.Analytical chemistry · 2014Article
- Reagentless, ratiometric electrochemical DNA sensors with improved robustness and reproducibility.Analytical chemistry · 2014Article
- Intraduplex DNA-mediated electrochemistry of covalently tethered redox-active reporters.Journal of the American Chemical Society · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Transcription factor expression levels, which sensitively reflect cellular development and disease state, are typically monitored via cumbersome, reagent-intensive assays that require relatively large quantities of cells. Here, we demonstrate a simple, quantitative approach to their detection based on a simple, electrochemical sensing platform. This sensor sensitively and quantitatively detects its target transcription factor in complex media (e.g., 250 μg/mL crude nuclear extracts) in a convenient, low-reagent process requiring only 10 μL of sample. Our approach thus appears a promising means of monitoring transcription factor levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.