ArticleDiabetes technology & therapeutics2012
Hypoglycemia, but not glucose variability, relates to vascular function in children with type 1 diabetes.
Article in Diabetes technology & therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Early Endothelial Dysfunction in Type 1 Diabetes Is Accompanied by an Impairment of Vascular Smooth Muscle Function: A Meta-Analysis.Frontiers in endocrinology · 2020Pooled it
- ISPAD Clinical Practice Consensus Guidelines 2018: Microvascular and macrovascular complications in children and adolescents.Pediatric diabetes · 2018Guideline
- Continuous glucose monitoring after islet transplantation in type 1 diabetes: an excellent graft function (β-score greater than 7) Is required to abrogate hyperglycemia, whereas a minimal function is necessary to suppress severe hypoglycemia (β-score greater than 3).The Journal of clinical endocrinology and metabolism · 2012Trial
- Continuous Glucose Monitoring-Derived Metrics and Cardiovascular Risk Among People With Diabetes: Systematic Scoping Review.JMIR diabetes · 2026Review
- Effect of breaking up sitting with regular active breaks on glucose management and vascular function in adults with type 1 diabetes who use hybrid closed-loop insulin delivery systems: a randomised crossover trial protocol.BMJ open sport & exercise medicine · 2026Article
- Complications of Diabetes and Metrics of Glycemic Management Derived From Continuous Glucose Monitoring.The Journal of clinical endocrinology and metabolism · 2022Review
- Post-Bariatric Hypoglycemia Is Associated with Endothelial Dysfunction and Increased Oxidative Stress.Biomedicines · 2022Article
- Glucose Variability: How Does It Work?International journal of molecular sciences · 2021Review
- Vascular Complication in Adolescents With Diabetes Mellitus.Frontiers in endocrinology · 2020Review
- Nanotechnology in cell replacement therapies for type 1 diabetes.Advanced drug delivery reviews · 2019Review
- Management of diabetes complications in youth.Therapeutic advances in endocrinology and metabolism · 2019Review
- Hypoglycemia does not affect the progression of preclinical atherosclerosis in subjects with type 2 diabetes.PloS one · 2019Article
- Mitochondrial regulation of diabetic vascular disease: an emerging opportunity.Translational research : the journal of laboratory and clinical medicine · 2018Review
- Macrovascular disease and risk factors in youth with type 1 diabetes: time to be more attentive to treatment?The lancet. Diabetes & endocrinology · 2018Review
- Relationship of Hyperglycaemia, Hypoglycaemia, and Glucose Variability to Atherosclerotic Disease in Type 2 Diabetes.Journal of diabetes research · 2018Article
- Higher-Than-Conventional Subcutaneous Regular Insulin Doses Following Diabetic Ketoacidosis in Children and AdolescentsJournal of clinical research in pediatric endocrinology · 2017Article
- Glucose variability, HbA1c and microvascular complications.Reviews in endocrine & metabolic disorders · 2016Review
- Impact of Real-Time Continuous Glucose Monitoring Use on Glucose Variability and Endothelial Function in Adolescents with Type 1 Diabetes: New Technology--New Possibility to Decrease Cardiovascular Risk?Journal of diabetes research · 2016Article
- Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes.World journal of diabetes · 2015Review
- Relationship between fluctuations in glucose levels measured by continuous glucose monitoring and vascular endothelial dysfunction in type 2 diabetes mellitus.Cardiovascular diabetology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic sustained hyperglycemia unequivocally predicts vascular disease in diabetes. However, the vascular risk of glucose variability, including hypoglycemia, is uncertain. Vascular dysfunction is present in children with type 1 diabetes and is a critical precursor of atherosclerosis. We aimed to evaluate the relationship between glucose variability and vascular function in children with type 1 diabetes. SUBJECTS AND
methodsFifty-two type 1 diabetes subjects (14 [SD 2.7] years old, 25 males) had continuous glucose monitoring that included 48 h of data used to evaluate glucose variability (mean amplitude of glycemic excursions [MAGE] and other measurements) and hypoglycemia indices (glycemic risk assessment diabetes equation [GRADE] hypoglycemia, Low Blood Glucose Index [LBGI], and observed duration of hypoglycemia). Children with type 1 diabetes and 50 age- and gender-matched controls had assessments of vascular function (flow-mediated dilatation [FMD] and glyceryl trinitrate-mediated dilatation [GTN]).
resultsChildren with type 1 diabetes had lower FMD and GTN than controls (P=0.02 and P<0.001, respectively). GRADE hypoglycemia and LBGI were inversely related to FMD (r=-0.36, P=0.009 and r=-0.302, P=0.03, respectively) but did not relate to GTN. GRADE hypoglycemia was independently related to FMD (regression coefficient=-0.25±0.09, P=0.006). MAGE and other measurements of glucose variability measurements did not relate to FMD or GTN.
conclusionsHypoglycemia, but not glucose variability, during continuous glucose monitoring relates to impaired vascular endothelial function in children with type 1 diabetes. Hypoglycemia may be an additional risk factor for early cardiovascular disease, but the effect of glucose variability, independent of glycosylated hemoglobin, on vascular function remains uncertain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.