ArticleBiomedical optics express2012
Mitochondrial redox studies of oxidative stress in kidneys from diabetic mice.
Article in Biomedical optics express, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Label-free whole-kidney metabolic optical imaging usingBiomedical optics express · 2025Article
- Optical Imaging Demonstrates Tissue-Specific Metabolic Perturbations in Mblac1 Knockout Mice.IEEE journal of translational engineering in health and medicine · 2024Article
- Thrombospondin-1 in maladaptive aging responses: a concept whose time has come.American journal of physiology. Cell physiology · 2020Review
- Fluorescence Imaging of Mitochondrial Redox State to Assess Diabetic Wounds.IEEE journal of translational engineering in health and medicine · 2019Article
- Pancreatic mitochondrial complex I exhibits aberrant hyperactivity in diabetes.Biochemistry and biophysics reports · 2017Article
- Endogenous Two-Photon Excited Fluorescence Imaging Characterizes Neuron and Astrocyte Metabolic Responses to Manganese Toxicity.Scientific reports · 2017Article
- The impact of aging, hearing loss, and body weight on mouse hippocampal redox state, measured in brain slices using fluorescence imaging.Neurobiology of aging · 2016Article
- Quantitative non-invasive cell characterisation and discrimination based on multispectral autofluorescence features.Scientific reports · 2016Article
- Organ specific optical imaging of mitochondrial redox state in a rodent model of hereditary hemorrhagic telangiectasia-1.Journal of biophotonics · 2014Article
- Optical imaging of mitochondrial redox state in rodent models with 3-iodothyronamine.Experimental biology and medicine (Maywood, N.J.) · 2014Article
- OPTICAL IMAGING OF LIPOPOLYSACCHARIDE-INDUCED OXIDATIVE STRESS IN ACUTE LUNG INJURY FROM HYPEROXIA AND SEPSIS.Journal of innovative optical health sciences · 2013Article
- Surface fluorescence studies of tissue mitochondrial redox state in isolated perfused rat lungs.Annals of biomedical engineering · 2013Article
- Optical imaging of mitochondrial redox state in rodent model of retinitis pigmentosa.Journal of biomedical optics · 2013Article
- Optical imaging of tissue mitochondrial redox state in intact rat lungs in two models of pulmonary oxidative stress.Journal of biomedical optics · 2012Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic hyperglycemia during diabetes leads to increased production of reactive oxygen species (ROS) and increased oxidative stress (OS). Here we investigated whether changes in the metabolic state can be used as a marker of OS progression in kidneys. We examined redox states of kidneys from diabetic mice, Akita(/+) and Akita(/+);TSP1(-/-) mice (Akita mice lacking thrombospondin-1, TSP1) with increasing duration of diabetes. OS as measured by mitochondrial redox ratio (NADH/FAD) was detectable shortly after the onset of diabetes and further increased with the duration of diabetes. Thus, cryo fluorescence redox imaging was used as a quantitative marker of OS progression in kidneys from diabetic mice and demonstrated that alterations in the oxidative state of kidneys occur during the early stages of diabetes.
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