ArticleInternational journal of molecular sciences2012
Antiproliferative and apoptotic effects triggered by Grape Seed Extract (GSE) versus epigallocatechin and procyanidins on colon cancer cell lines.
Article in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 89 citations in OpenAlex.
- α- and β-Casein Differentially Protect Anthocyanins from Three Red Grape (Foods (Basel, Switzerland) · 2026Article
- Improving Soluble Phenolic Profile and Antioxidant Activity of Grape Pomace Seeds through Fungal Solid-State Fermentation.Foods (Basel, Switzerland) · 2024Article
- Protective Effect of Procyanidin-Rich Grape Seed Extract against Gram-Negative Virulence Factors.Antibiotics (Basel, Switzerland) · 2023Article
- Beneficial Effects of Table Grape Use on Serum Levels of Omega-3 Index and Liver Function: A Randomized Controlled Clinical Trial.Biomedicines · 2022Article
- Grape seed proanthocyanidin extract inhibits DNA and protein damage and labile iron, enzyme, and cancer cell activities.Scientific reports · 2022Article
- Polyphenol Extract from "Greco" Grape Canes: Characterization, Antioxidant Capacity, and Antitumor Effects on Cal-33 and JHU-SCC-011 Head and Neck Squamous Cell Carcinoma.Molecules (Basel, Switzerland) · 2022Article
- Correlation between antioxidant and anticancer activity and phenolic profile of new Apulian table grape genotypes (Frontiers in plant science · 2022Article
- HRMS Characterization, Antioxidant and Cytotoxic Activities of Polyphenols inMolecules (Basel, Switzerland) · 2021Article
- Polyphenolic QTOF-ESI MS Characterization and the Antioxidant and Cytotoxic Activities ofMolecules (Basel, Switzerland) · 2021Article
- A Ten-Day Grape Seed Procyanidin Treatment Prevents Certain Ageing Processes in Female Rats over the Long Term.Nutrients · 2020Article
- Antifungal Activity of Phenolic and Polyphenolic Compounds from Different Matrices ofMolecules (Basel, Switzerland) · 2020Review
- Flavonoid and Non-Flavonoid Compounds of Autumn Royal and Egnatia Grape Skin Extracts Affect Membrane PUFA's Profile and Cell Morphology in Human Colon Cancer Cell Lines.Molecules (Basel, Switzerland) · 2020Article
- Phytochemical Composition, Antioxidant and Antiproliferative Activities of Defatted Sea Buckthorn (Antioxidants (Basel, Switzerland) · 2020Article
- Stearoyl-CoA Desaturase-1 Enzyme Inhibition by Grape Skin Extracts Affects Membrane Fluidity in Human Colon Cancer Cell Lines.Nutrients · 2020Article
- Effect of Juice and Extracts fromInternational journal of molecular sciences · 2019Article
- Antiproliferative and cytotoxic effects of grape pomace and grape seed extracts on colorectal cancer cell lines.Food science & nutrition · 2019Article
- Grape seed procyanidin extract against lung cancer: the role of microrna-106b, bioavailability, and bioactivity.Oncotarget · 2018Article
- Cancer Chemopreventive Potential of Procyanidin.Toxicological research · 2017Review
- Protective effects of grape seed and skin extract against high-fat-diet-induced lipotoxicity in rat lung.Lipids in health and disease · 2017Article
- Prodelphinidins isolated from Chinese bayberry leaves induces apoptosis via the p53-dependent signaling pathways in OVCAR-3 human ovarian cancer cells.Oncology letters · 2017Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Grape seed extract has been proven to exert anticancer effects on different tumors. These effects are mainly ascribed to catechin and procyanidin content. Analytical studies demonstrated that grape seed extract composition is complex and it is likely other components could exert biological activities. Using cell count and flow cytometry assays, we evaluated the cytostatic and apoptotic effects produced by three different grape seed extracts from Italia, Palieri and Red Globe cultivars, on Caco2 and HCT-8 colon cancer cells. These effects were compared to those induced by epigallocatechin and procyanidins, alone or in association, on the same cell lines. All the extracts induced growth inhibition and apoptosis in Caco2 and HCT-8 cells, along the intrinsic apoptotic pathway. On both cell lines, growth inhibition induced by Italia and Palieri grape seed extracts was significantly higher than that it has been recorded with epigallocatechin, procyanidins and their association. In Caco2 cells, the extract from Red Globe cultivar was less effective in inducing growth inhibition than procyanidins alone and in association with epigallocatechin, whereas, in HCT-8 cells, only the association of epigallocatechin and procyanidins triggers a significant proliferation decrease. On both cell lines, apoptosis induced by Italia, Palieri and Red Globe grape seed extracts was considerably higher than has been recorded with epigallocatechin, procyanidins and their association. These data support the hypothesis by which other compounds, present in the grape seed extracts, are likely to enhance the anticancer effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.