ArticleMolecular vision2012
Non-housekeeping genes expressed in human trabecular meshwork cell cultures.
Article in Molecular vision, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Epigenetics of glaucoma in the trabecular meshwork.Clinical epigenetics · 2025Review
- Construction of miRNA-mRNA regulatory network indicates potential biomarkers for primary open-angle glaucoma.BMC medical genomics · 2023Article
- Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies.Nature communications · 2021Article
- The Future of Stem Cells and Their Derivates in the Treatment of Glaucoma. A Critical Point of View.International journal of molecular sciences · 2021Review
- Article
- A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling.Experimental eye research · 2021Article
- miR‑17‑5p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting phosphatase and tensin homolog.Molecular medicine reports · 2019Article
- Identification of Candidate miRNA Biomarkers for Glaucoma.Investigative ophthalmology & visual science · 2019Article
- Genomic Locus Modulating IOP in the BXD RI Mouse Strains.G3 (Bethesda, Md.) · 2018Article
- Identification of genes associated with primary open-angle glaucoma by bioinformatics approach.International ophthalmology · 2018Article
- Model systems for the study of steroid-induced IOP elevation.Experimental eye research · 2017Review
- Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium.PLoS genetics · 2016Article
- Endothelial nitric oxide synthase deficiency influences normal cell cycle progression and apoptosis in trabecular meshwork cells.International journal of ophthalmology · 2016Article
- MicroRNAs that target RGS5.Iranian journal of basic medical sciences · 2015Article
- Genotype-phenotype analysis of SNPs associated with primary angle closure glaucoma (rs1015213, rs3753841 and rs11024102) and ocular biometry in the EPIC-Norfolk Eye Study.The British journal of ophthalmology · 2013Article
- Ocular hypertension following intravitreal anti-vascular endothelial growth factor agents.Drugs & aging · 2012Review
- Human trabecular meshwork cells exhibit several characteristics of, but are distinct from, adipose-derived mesenchymal stem cells.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and TherapeuticsArticle
- Role of microRNAs in the trabecular meshwork.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and TherapeuticsReview
- Glaucoma in iran and contributions of studies in iran to the understanding of the etiology of glaucoma.Journal of ophthalmic & vision researchReview
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo identify non-housekeeping genes definitively expressed in the human trabecular meshwork (TM).
methodsMicroarray gene expression data on TM cultured cells from four studies were compared. Genes that were queried in at least three studies and assessed to be expressed in at least three studies were considered definitively expressed genes of the human TM. Housekeeping genes were removed from this set of genes. The non-housekeeping TM gene profile was analyzed for pathway enrichment and microRNA targeting, using bioinformatics tools. The results were compared with results of previous non-array based studies.
resultsNine hundred and sixty-two genes were identified as non-housekeeping TM expressed genes. Analysis of these by Kyoto Encyclopedia of Genes and Genomes led to identification of two enriched biologic pathways that achieved a highly significant Bonferroni p-value (p≤0.01): focal adhesion and extracellular matrix (ECM)-receptor interaction. Many of the genes were previously implicated in TM-related functions and the TM-associated disease glaucoma; however, some are novel. MicroRNAs known to be expressed in the trabecular meshwork were predicted to target some of the genes. Ten genes identified here, ALDH1A1 (aldehyde dehydrogenase 1 family, member A1), CDH11 (cadherin 11, type 2, OB-cadherin), CXCR7 (chemokine (C-X-C motif) receptor 7), CHI3L1 (chitinase 3-like 1), FGF2 (fibroblast growth factor 2), GNG11 (guanine nucleotide binding protein [G protein], gamma 11), IGFBP5 (insulin-like growth factor binding protein 5), PTPRM (protein tyrosine phosphatase, receptor type, M), RGS5 (regulator of G-protein signaling 5), and TUSC3 (tumor suppressor candidate 3), were also reported as TM expressed genes in three earlier non-microarray based studies.
conclusionsA transcriptome consisting of 962 non-housekeeping genes definitively expressed in the human TM was identified. Multiple genes and microRNAs are proposed for further study for a better understanding of TM physiology.
Indexed as
Identifiers
22312193PMC3272053W1564186693What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.