Trial reportArchives of pediatrics & adolescent medicine2012
Human immunodeficiency virus disease severity, psychiatric symptoms, and functional outcomes in perinatally infected youth.
Trial report in Archives of pediatrics & adolescent medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence and factors associated with common mental disorders in young people living with HIV in sub-Saharan Africa: a systematic review.Journal of the International AIDS Society · 2021Pooled it
- School functioning of children with perinatal HIV-infection in high-income countries: A systematic review.PloS one · 2021Pooled it
- Emotional and behavioral resilience among children with perinatally acquired HIV in Thailand and Cambodia.AIDS (London, England) · 2019Trial
- Impact of antiretroviral therapy on quality of life in HIV-infected Southeast Asian children in the PREDICT study.AIDS patient care and STDs · 2013Trial
- Cognitive function and neurodevelopmental outcomes in HIV-infected Children older than 1 year of age randomized to early versus deferred antiretroviral therapy: the PREDICT neurodevelopmental study.The Pediatric infectious disease journal · 2013Trial
- Tablet-Based Neurocognitive Tests for Ugandan Adolescents Living With HIV: Cross-Sectional Validation Study.JMIR mHealth and uHealth · 2026Article
- Infectious diseases and childhood disruptive behavior disorders: a reappraisal.Frontiers in cellular and infection microbiology · 2026Article
- Are Family Factors Differentially Associated with Externalizing Symptoms Among Youth with Perinatally Acquired HIV?Child psychiatry and human development · 2025Article
- Article
- Relationship between brain structural network integrity and emotional symptoms in youth with perinatally-acquired HIV.Brain, behavior, and immunity · 2024Article
- Acceptability and Feasibility of Genetic Testing to Assess Risk of HIV-Associated Neurocognitive Impairment Among Thai Adolescents and Young Adults.AIDS research and human retroviruses · 2023Article
- Adaptation and construct validity evaluation of a tablet-based, short neuropsychological test battery for use with adolescents and young adults living with HIV in Thailand.Neuropsychology · 2022Article
- HIV-Related Stigma and Psychological Adjustment Among Perinatally HIV-Infected Youth in Cape Town, South Africa.AIDS and behavior · 2022Article
- Prevalence, Risk Factors, and Negative Outcomes of Anxiety and Depressive Disorders among HIV-Infected Children and Adolescents in Uganda: CHAKA Study 2014-2017.Psychiatry journal · 2022Article
- TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV+ children and adolescents in Uganda.BMC medical genomics · 2021Article
- Association of Stress, Glucocorticoid Receptor, and FK506 Binding Protein Gene Polymorphisms With Internalizing Disorders Among HIV-Infected Children and Adolescents From Kampala and Masaka Districts-Uganda.Frontiers in pediatrics · 2021Article
- TheFrontiers in genetics · 2021Article
- Family Contextual Factors are Differentially Associated with Depressive Symptoms among Boys and Girls with Perinatally Acquired HIV.AIDS and behavior · 2021Article
- State of the Mind: Growing up with HIV.Paediatric drugs · 2020Review
- Neurodevelopment of HIV-Exposed Uninfected Infants Born to Women With Perinatally Acquired HIV in the United States.Journal of acquired immune deficiency syndromes (1999) · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo evaluate associations between human immunodeficiency virus (HIV) disease severity and psychiatric and functional outcomes in youth with perinatal HIV infection.
designCross-sectional analysis of entry data from an observational,prospective 2-year study.Logistic and linear regression models adjusted for potential confounders were used.
settingTwenty-nine sites of the International Maternal Pediatrics Adolescent AIDS Clinical Trials Group study in the United States and Puerto Rico.
participantsYouth aged 6 to 17 years who had HIV infection (N=319). MAIN EXPOSURES: Antiretroviral treatment and perinatal HIV infection.
main outcome measuresYouth and primary caregivers were administered an extensive battery of measures that assessed psychiatric symptoms; cognitive, social,and academic functioning; and quality of life.
resultsCharacteristics of HIV were a current CD4 percentage of 25% or greater (74% of participants), HIV RNA levels of less than 400 copies/mL (59%), and current highly active antiretroviral therapy (81%). Analyses indicated associations of past and current Centers for Disease Control and Prevention class C designation with less severe attention-deficit/hyperactivity disorder inattention symptoms,older age at nadir CD4 percentage and lower CD4 percentage at study entry with more severe conduct disorder symptoms,higher RNA viral load at study entry with more severe depression symptoms, and lower CD4 percentage atstudy entry with less severe symptoms of depression. There was little evidence of an association between specific antiretroviral therapy and severity of psychiatric symptoms.A lower nadir CD4 percentage was associated with lower quality of life, worse Wechsler Intelligence Scale for Children Coding Recall scores, and worse social functioning.
conclusionHuman immunodeficiency virus illness severity markers are associated with the severity of some psychiatric symptoms and, notably, with cognitive, academic,and social functioning, all of which warrant additional study.
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