ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2012
Human population structure and the adaptive response to pathogen-induced selection pressures.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- What has population genomics told us about the dynamics of selection and plant adaptation?Molecular biology and evolution · 2026Review
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- Population genetic models for the spatial spread of adaptive variants: A review in light of SARS-CoV-2 evolution.PLoS genetics · 2022Review
- Review
- Pathogenicity and virulence ofVirulence · 2021Review
- Known Mutations at the Cause of Alpha-1 Antitrypsin Deficiency an Updated Overview ofThe application of clinical genetics · 2021Review
- Article
- Polygenic adaptation: From sweeps to subtle frequency shifts.PLoS genetics · 2019Article
- Of genes and microbes: solving the intricacies in host genomes.Protein & cell · 2018Review
- Whole-genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selection.Genome research · 2016Article
- Variation in NAT2 acetylation phenotypes is associated with differences in food-producing subsistence modes and ecoregions in Africa.BMC evolutionary biology · 2015Article
- Extensive Admixture and Selective Pressure Across the Sahel Belt.Genome biology and evolution · 2015Article
- The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease.Current opinion in immunology · 2014Review
- Demographic events and evolutionary forces shaping European genetic diversity.Cold Spring Harbor perspectives in biology · 2014Review
- Population genomics of rapid adaptation by soft selective sweeps.Trends in ecology & evolution · 2013Review
- Article
- Diverse approaches to analysing the history of human and pathogen evolution: how to tell the story of the past 70 000 years.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Article
- The molecular pathways underlying host resistance and tolerance to pathogens.Frontiers in genetics · 2012Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The past few years of research in human evolutionary genetics have provided novel insights and questions regarding how human adaptations to recent selective pressures have taken place. Here, we review the advances most relevant to understanding human evolution in response to pathogen-induced selective pressures. Key insights come from theoretical models of adaptive evolution, particularly those that consider spatially structured populations, and from empirical population genomic studies of adaptive evolution in humans. We also review the CCR5-Δ32 HIV resistance allele as a case study of pathogen resistance in humans. Taken together, the results make clear that the human response to pathogen-induced selection pressures depends on a complex interplay between the age of the pathogen, the genetic basis of potential resistance phenotypes, and how population structure impacts the adaptive process in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.