ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2012
Insights from genomic comparisons of genetically monomorphic bacterial pathogens.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 138 citations in OpenAlex.
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- Gene conversion and duplication contribute to genetic variation in an outbreak ofMicrobial genomics · 2025Article
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- Evolutionary Processes in the Emergence and Recent Spread of the Syphilis Agent, Treponema pallidum.Molecular biology and evolution · 2022Article
- Multi-Omics Approach in Amelioration of Food Products.Frontiers in microbiology · 2022Review
- SplitStrains, a tool to identify and separate mixedMicrobial genomics · 2021Article
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- Cryptic speciation of a pelagic Roseobacter population varying at a few thousand nucleotide sites.The ISME journal · 2020Article
- Comparative genomics of whole-cell pertussis vaccine strains from India.BMC genomics · 2020Article
- Model-based integration of genomics and metabolomics reveals SNP functionality inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex.Nature communications · 2019Article
- Deciphering how plant pathogenic bacteria disperse and meet: Molecular epidemiology ofEvolutionary applications · 2019Article
- Phages for Phage Therapy: Isolation, Characterization, and Host Range Breadth.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Fast and flexible bacterial genomic epidemiology with PopPUNK.Genome research · 2019Article
- Genome-wide identification of geographical segregated genetic markers in Salmonella enterica serovar Typhimurium variant 4,[5],12:i:.Scientific reports · 2018Article
- Role of genomics in promoting the utilization of plant genetic resources in genebanks.Briefings in functional genomics · 2018Review
- Genomic divergence and cohesion in a species of pelagic freshwater bacteria.BMC genomics · 2017Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some of the most deadly bacterial diseases, including leprosy, anthrax and plague, are caused by bacterial lineages with extremely low levels of genetic diversity, the so-called 'genetically monomorphic bacteria'. It has only become possible to analyse the population genetics of such bacteria since the recent advent of high-throughput comparative genomics. The genomes of genetically monomorphic lineages contain very few polymorphic sites, which often reflect unambiguous clonal genealogies. Some genetically monomorphic lineages have evolved in the last decades, e.g. antibiotic-resistant Staphylococcus aureus, whereas others have evolved over several millennia, e.g. the cause of plague, Yersinia pestis. Based on recent results, it is now possible to reconstruct the sources and the history of pandemic waves of plague by a combined analysis of phylogeographic signals in Y. pestis plus polymorphisms found in ancient DNA. Different from historical accounts based exclusively on human disease, Y. pestis evolved in China, or the vicinity, and has spread globally on multiple occasions. These routes of transmission can be reconstructed from the genealogy, most precisely for the most recent pandemic that was spread from Hong Kong in multiple independent waves in 1894.
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